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dc.contributor.authorO'TOOLE, RONANen
dc.date.accessioned2017-01-12T12:46:32Z
dc.date.available2017-01-12T12:46:32Z
dc.date.created2016en
dc.date.issued2016en
dc.date.submitted2016en
dc.identifier.citationO'Toole R.F, Shukla S.D, Walters E.H, Does upregulated host cell receptor expression provide a link between bacterial adhesion and chronic respiratory disease?, Journal of Translational Medicine, 14, 1, 2016en
dc.identifier.otherYen
dc.identifier.urihttp://hdl.handle.net/2262/78697
dc.description.abstractAbstract Expression of the platelet-activating factor receptor is upregulated in the respiratory epithelium of smokers and chronic obstructive pulmonary disease patients. We have recently determined that increased expression of PAFr cor - relates with higher levels of adhesion to human bronchial epithelial cells by non-typable Haemophilus influenzae and Streptococcus pneumoniae which are major bacterial pathogens in acute exacerbations of COPD. In addition, we found that a PAFr antagonist decreased the adhesion of both respiratory bacterial pathogens to non-cigarette exposure con - trol levels. This highlights the possibility that epithelial receptors, that are upregulated in response to cigarette smoke, could be targeted to specifically block chronic bacterial infections of the lower respiratory tract. In this commentary, we explore the question of whether adhesion to a temporally-upregulated host receptor is a common event in chronic bacterial disease, and as such, could represent a putative therapeutic target for blocking infection by respira- tory and other pathogens.en
dc.description.sponsorshipAcknowledgements The authors would like to acknowledge the support of the School of Medi- cine, Faculty of Health, University of Tasmania.en
dc.relation.ispartofseriesJournal of Translational Medicineen
dc.relation.ispartofseries14en
dc.relation.ispartofseries1en
dc.rightsYen
dc.subjectAirway epithelium, Platelet-activating factor receptor, Non-typeable Haemophilus influenzae , Streptococcus pneumoniaeen
dc.subject.lcshAirway epithelium, Platelet-activating factor receptor, Non-typeable Haemophilus influenzae , Streptococcus pneumoniaeen
dc.titleDoes upregulated host cell receptor expression provide a link between bacterial adhesion and chronic respiratory disease?en
dc.typeJournal Articleen
dc.type.supercollectionscholarly_publicationsen
dc.type.supercollectionrefereed_publicationsen
dc.identifier.peoplefinderurlhttp://people.tcd.ie/otooler3en
dc.identifier.rssinternalid141859en
dc.identifier.doihttp://dx.doi.org/10.1186/s12967-016-1063-xen
dc.rights.ecaccessrightsopenAccess
dc.identifier.rssurihttps://www.scopus.com/inward/record.uri?eid=2-s2.0-84992365971&doi=10.1186%2fs12967-016-1063-x&partnerID=40&md5=8f83ecfa8b1cd36103924e5ecbae5018en


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