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dc.contributor.advisorGilmer, John
dc.contributor.advisorRadomski, Marek
dc.contributor.authorWang, Jun
dc.date.accessioned2016-12-05T16:26:11Z
dc.date.available2016-12-05T16:26:11Z
dc.date.issued2010
dc.identifier.citationJun Wang, 'The design, synthesis and biological evaluation of novel barbiturate-based MMP inhibitors', [thesis], Trinity College (Dublin, Ireland). School of Pharmacy & Pharmaceutical Sciences, 2010, pp 331
dc.identifier.otherTHESIS 9549
dc.identifier.urihttp://hdl.handle.net/2262/78245
dc.description.abstractMatrix metalloproteinases (MMPs) are a group of Zn-dependent endopeptidases that participate in many diseases. Two MMPs, MMP-2 and MMP-9, which are especially associated with inflammatory diseases and tumor metastasis have been considered as promising target for arthritis, stroke, IBD, various pulmonary disorders and cancer. A great number of MMP inhibitors have been reported and are classified into different groups based on their structure, including hydroxamates, carboxylates, and thiols. Although some of these compounds exhibit great potency on inhibition of MMPs, their clinical trial results are disappointed due to lack of selectivity. Recently, appropriate C-5 substituted barbiturates have been found to show MMP inhibitory effects. Since barbiturates have been used as sedatives and hypnotics for decades and have well established clinical history, the MMP inhibitors we prepared were based on the structure of barbiturate.
dc.format1 volume
dc.language.isoen
dc.publisherTrinity College (Dublin, Ireland). School of Pharmacy & Pharmaceutical Sciences
dc.relation.isversionofhttp://stella.catalogue.tcd.ie/iii/encore/record/C__Rb15116426
dc.subjectPharmaceutical Chemistry, Ph.D.
dc.subjectPh.D. Trinity College Dublin
dc.titleThe design, synthesis and biological evaluation of novel barbiturate-based MMP inhibitors
dc.typethesis
dc.type.supercollectionthesis_dissertations
dc.type.supercollectionrefereed_publications
dc.type.qualificationlevelDoctoral
dc.type.qualificationnameDoctor of Philosophy (Ph.D.)
dc.rights.ecaccessrightsopenAccess
dc.format.extentpaginationpp 331
dc.description.noteTARA (Trinity’s Access to Research Archive) has a robust takedown policy. Please contact us if you have any concerns: rssadmin@tcd.ie


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