Collections in this Academic/Research Unit

Recent Submissions

  • Stability and hydrolysis studies of novel dual acting conjugate drugs with anitcancer activity 

    Yassin, Bassem I. (Trinity College (Dublin, Ireland). School of Pharmacy & Pharmaceutical Sciences, 2011)
    Tamoxifen is currently a first-line endocrine therapy for the adjuvant treatment of Estrogen Receptor (ER) positive breast cancer. The antiestrogenic properties of this compound are related to its ability to compete for ...
  • Investigations of beta-lactams as novel bioactive compounds 

    Wang, Shu (Trinity College (Dublin, Ireland). School of Pharmacy & Pharmaceutical Sciences, 2013)
    A natural stilbene product combretastatin A-4 (CA-4) is a known anti-cancer compound, which exerts its mechanism of action at the colchicine binding site on tubulin, a protein that is essential for the replication of cells. ...
  • The design, synthesis and biological evaluation of novel barbiturate-based MMP inhibitors 

    Wang, Jun (Trinity College (Dublin, Ireland). School of Pharmacy & Pharmaceutical Sciences, 2010)
    Matrix metalloproteinases (MMPs) are a group of Zn-dependent endopeptidases that participate in many diseases. Two MMPs, MMP-2 and MMP-9, which are especially associated with inflammatory diseases and tumor metastasis have ...
  • Flexible estrogen receptor modulators 

    Smith, Helena M. (Trinity College (Dublin, Ireland). School of Pharmacy & Pharmaceutical Sciences, 2005)
    Tamoxifen is a selective estrogen receptor modulator (SERM) with a triarylethylene structure, which has estrogenic activity in bone and endometrial tissue, yet antagonises the actions of estrogen in other tissues including ...
  • Characterisation and analysis of beta-aminoketones as potential prodrugs for amines 

    Simplício, Ana Luísa Ferreira (Trinity College (Dublin, Ireland). School of Pharmacy & Pharmaceutical Sciences, 2004)
    The aim of the work described in this thesis is to evaluate the potential of β-aminoketones as amine prodrugs. These compounds are usually stable in acidic conditions while they cleave into the parent amine and an ...

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