A novel method for the measurement of flow-induced platelet activation at nanoscale resolution level
Citation:María José Santos-Martínez, 'A novel method for the measurement of flow-induced platelet activation at nanoscale resolution level', [thesis], Trinity College (Dublin, Ireland). School of Pharmacy & Pharmaceutical Sciences, 2009, pp 157
Santos Martinez TCD THESIS 9208 A novel.pdf (PDF) 92.08Mb
Background: Platelet aggregation Is essential for vascular haemostasis and thrombosis. Inhibition of platelet aggregation underpins the pharmacological and clinical effects of antiplatelet drugs. These effects are commonly quantified using methods and devices that assess platelet aggregation under static conditions in macroscale. However, current devices neither mimic the conditions found in human microvasculature nor detect microaggregates. Aim: To provide pharmacological characteristics of a novel method of flow- induced platelet aggregation using a commercially available nanoscale resolution device, the Quartz Crystal Microbalance with Dissipation (Q-Sense™ E4).
Author: Santos-Martínez, María José
Advisor:Radomski, Marek W.
Qualification name:Doctor of Philosophy (Ph.D.)
Publisher:Trinity College (Dublin, Ireland). School of Pharmacy & Pharmaceutical Sciences
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Type of material:thesis
Availability:Full text available