Preparation and characterisation of spray dried composites of pharmaceutical materials
Citation:
Deirdre Olive Corrigan, 'Preparation and characterisation of spray dried composites of pharmaceutical materials', [thesis], Trinity College (Dublin, Ireland). School of Pharmacy & Pharmaceutical Sciences, 2003, pp 345Download Item:
Corrigan TCD THESIS 7172 Preparation and.pdf (PDF) 236.5Mb
Abstract:
The solid state properties of a range of spray dried excipients and drugs and co-spray dried excipient/excipient, drug/excipient and drug/drug, systems were investigated. The excipients investigated were lactose, polyethylene glycol 4000, polyethylene glycol 20,000, polyethylene oxide 300,000 and chitosan. The drugs investigated were bendroflumethiazide, salbutamol sulphate, salbutamol base, ipratropium bromide monohydrate, budesonide and formoterol fumarate dihydrate. The methods of analysis used to characterise the spray dried systems were powder X-ray diffraction (XRD), differential scanning calorimetry (DSC), thermogravimetric analysis (TGA), Fourier Transform Infrared spectroscopy (FTIR) and scanning electron microscopy (SEM). Energy dispersive X-ray analysis was performed on some samples to determine the presence of certain elements. The effect of co-spray drying lactose with PEG 4000 on the recrystallisation rate of lactose was studied under differing temperature and humidity conditions. Release studies were performed on BFMT/PEG 4000 systems to assess the effect of the modification of the solid-state properties on the dissolution behaviour of BFMT present in the BFMT/PEG co-spray dried composites. Twin stage impinger (TSI) experiments were carried out on systems which had potential for inhalation therapy. Lactose, chitosan, BFMT, salbutamol sulphate and budesonide spray dried alone were X- ray amorphous. Formoterol fumarate was not spray dried alone in this work but was known to form an amorphous composite on spray drying. Chitosan starting material was amorphous while the other materials were crystalline prior to spray drying. The polyethylene glycol/oxides of various molecular weights, salbutamol base and ipratropium bromide did not form X-ray amorphous phases on spray drying. Some reduction in crystallinity was observed for PEG 4000, PEO 300,000 and salbutamol base. Salbutamol base did consist of some amorphous material as evidenced by a recrystallisation exotherm by DSC. Ipratropium bromide spray dried from aqueous solution consisted of mainly the anhydrous form while spray drying from ethanolic solvent showed mainly the monohydrate form by XRD.
Author: Corrigan, Deirdre Olive
Advisor:
Healy, Anne-MarieQualification name:
Doctor of Philosophy (Ph.D.)Publisher:
Trinity College (Dublin, Ireland). School of Pharmacy & Pharmaceutical SciencesNote:
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Full text availableKeywords:
Pharmaceutics, Ph.D., Ph.D. Trinity College DublinLicences: