Browsing Trinity College Dublin Theses & Dissertations by Subject "Haematology, Ph.D."
Now showing items 1-8 of 8
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Cellular and molecular mechanisms associated with sensitivity to DNA damaging agents in various human genetic disorders
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Haematology, 2005)The integrity of the genome is important to cellular and organism homeostasis. It is under constant threat due to intrinsic and extrinsic factors which contribute to a variety of genetic alterations and so genomic integrity ... -
Detection of minimal residual disease and WT1 overexpression in childhood acute leukaemia
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Haematology, 2008)Minimal residual disease (MRD), the post-treatment presence of a small submicroscopic amount of leukaemic cells in the bone marrow or other sites undetectable by conventional methods, has been recently shown to be one of ... -
Drug-induced veno-occlusive disease of the liver : unravelling the role of the inflammatory and coagulation pathways
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Haematology, 2008)The thiopurines thioguanine (6TG) and mercaptopurine (6MP), along with Mylotarg (an antibody targeted agent), are used in the treatment of acute leukaemias. These drugs are more commonly associated with the development of ... -
Investigations into Pyrrolo-1,5-Benzoxazepine-15-induced apoptosis of chronic B-cell malignancies
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Haematology, 2009)Multiple myeloma and chronic lymphocytic leukaemia (CLL) are chronic B-cell malignancies, which are characterised by the accumulation of malignant cells with low proliferative capacity and defective apoptotic mechanisms. ... -
Isolation and characterisation of a monocyte protein C receptor : implications for novel therapeutic strategies in sepsis
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Haematology, 2003)The protein C (PC) pathway provides a unique interface between the processes of coagulation, inflammation and fibrinolysis. Used as an adjunct to standard treatment, PC/activated PC to date, has been shown to be the only ... -
Prognostic factors in chronic lymphocytic leukemia
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Haematology, 2008)Chronic lymphocytic leukaemia (CLL) is the most common leukaemia in the Western world, accounting for nearly 24% of all leukaemias. It is estimated that 7300 new cases were diagnosed in 2003 in the United States and there ... -
The coagulation & inflammation interface : the pathophysiological basis for disease states
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Haematology, 2003)The molecular and cellular pathways of coagulation and inflammation have traditionally been regarded as separate entities, however recent research has demonstrated that they are closely linked through endothelial and ... -
The role of glycosylation and sequence variation in the regulation of von Willebrand Factor plasma levels
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Haematology, 2014)Von Willebrand Factor (VWF) is a multimeric plasma sialoglycoprotein that plays an important role in primary haemostasis by mediating platelet capture at sites of vascular injury. In the normal population, VWF plasma ...