Browsing Trinity College Dublin Theses & Dissertations by Sponsor "Higher Education Authority (HEA)"
Now showing items 1-13 of 13
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Covalently cross-linked tetrafunctionalized m-THPC chitosan hydrogels as drug delivery platforms
(Trinity College Dublin. School of Chemistry. Discipline of Chemistry, 2022)Photodynamic therapy (PDT) is an anti-cancer treatment method which uses the combined effect of a photosensitizing drug, light, and oxygen to cause selective damage to target tissue. The second generation photosensitizer ... -
Enhancing Network Performance and Consumer Experience in Named Data Networking (NDN)
(Trinity College Dublin. School of Computer Science & Statistics. Discipline of Computer Science, 2020)Named Data Networking (NDN) is an Information-Centric Networking (ICN) architecture proposed as an alternative to the current Internet infrastructure. Using the publish-subscribe paradigm and a standardised naming scheme, ... -
Examining the Impact of Peacekeeping Operations on Soldiers' Militarized Masculinities: The Case of Korean Peacekeeping Soldiers
(Trinity College Dublin. School of Religion. Irish School of Ecumenics, 2023)Gender studies of militaries and the dynamics of war suggest that ideas of militarized masculinity are central to the creation of soldiers who are willing to fight and perhaps die in combat. With the rise of national ... -
Generation and Reactivity of Late Transition Metal Hydr(oxo) Complexes Supported by Tripodal Carboxamidate Ligand
(Trinity College Dublin. School of Chemistry. Discipline of Chemistry, 2022)Metal oxo complexes (M=O) are important mediators of oxidative transformations in biological systems.1 Their high reactivity and transient nature have limited their study, with only a handful of well characterized oxo ... -
Investigating the Impact of the Non-Structural Proteins of Respiratory Syncytial Virus on the Type I Interferon Response
(Trinity College Dublin. School of Biochemistry & Immunology. Discipline of Biochemistry, 2023)Respiratory syncytial virus is the leading cause of bronchiolitis in infants, causing 33.2 million hospital admissions and over 118,000 deaths each year. The primary site of RSV infection are the epithelial cells of the ... -
The Molecular Mechanisms of rhIGF1 in the Treatment of Rett Syndrome and Related Disorders: Studies in Patients, Mouse and Cellular Models
(Trinity College Dublin. School of Medicine. Discipline of Psychiatry, 2022)Recombinant human Insulin-like Growth Factor 1 (rhIGF1) is an approved treatment for growth failure and IGF1 deficiency. IGF1 has multiple functions in the body including growth, cell survival, metabolism, ageing and ... -
On the Synthesis and Utilization of geminal-Dimethyl Hydroporphyrins and Tetraphenylethylenes in Photodynamic Therapy
(Trinity College Dublin. School of Chemistry. Discipline of Chemistry, 2022)Chapter 1 introduces the main concepts of this thesis: photodynamic therapy (PDT), chlorins and photosensitizer arrays. In the case of PDT multiple topics are discussed, namely, the qualities of an ideal photosensitizer, ... -
Performing Religion and Spirituality: The Postsecular Turn in Contemporary British and Irish Theatre
(Trinity College Dublin. School of Creative Arts. Discipline of Drama, 2022)This thesis argues that there has been a postsecular turn on the contemporary stage, focussing in particular on woman-centred theatre in Britain and Ireland in the past three decades. It deals with the representation ... -
Pyrrole-based Photosensitisers for Photomedicine. Synthesis, Photophysical and Photobiological Evaluation of Chlorins and Dipyrrin Complexes
(Trinity College Dublin. School of Chemistry. Discipline of Chemistry, 2022)Photodynamic therapy (PDT) is a light activated therapy which involves a drug-photosensitiser (PS), light, and molecular oxygen. First, the PS is administered via a systemic or topical route and then it accumulates in the ... -
Re-evaluating the Role of SARM1 as a Transcriptional Regulator Using Improved Genome-Edited Mouse Models
(Trinity College Dublin. School of Biochemistry & Immunology. Discipline of Biochemistry, 2022)SARM1 is an ancient and highly conserved protein, initially described as having functions in innate immunity. In the last decade, our understanding of SARM1 structure and function expanded rapidly. The majority of research ... -
The role of nutrition as a determinant of clinical, immunological and pharmacological outcome in HIV-infected children in Uganda
(Trinity College Dublin. School of Medicine. Discipline of Immunology, 2019)Introduction: Perinatally acquired HIV infection and malnutrition remain major public health challenges for sub-Saharan Africa health systems. HIV and malnutrition result in 50% mortality. The introduction of antiretroviral ... -
Synthesis and analysis of Nile Red functionalised Ru(II) and Ir(III) photosensitisers
(Trinity College Dublin. School of Chemistry. Discipline of Chemistry, 2023)Nile Red (9-(diethylamino)-5H-benzo[a]phenoxazin-5-one) is a common organic dye that exhibits strong absorption of visible light, and is highly fluorescent. Despite these properties, examples of transition metal complexes ... -
What alternatives can BRICS countries offer to the world of global higher education? A thematic policy analysis of the WCU policies of BRICS nations through the lens of multiple modernities
(Trinity College Dublin. School of Education. Discipline of Education, 2021)The formation of higher education policy in BRICS nations, particularly in recent decades, has been increasingly affected by the advent of global educational trends, particularly those which have been laid down by the ...