Human Vγ9Vδ2 T cells: Innate adaptors of the immune system
Citation:
Tyler C., Doherty D., Moser B., Eberl M., Human Vγ9Vδ2 T cells: Innate adaptors of the immune system, Cellular Immunology, 296, 1, 2015, 10-21Download Item:
Abstract:
Unconventional T cells are gaining center stage as important effector and regulatory cells that orchestrate
innate and adaptive immune responses. Human Vc9/Vd2 T cells are amongst the best understood unconventional
T cells, as they are easily accessible in peripheral blood, can readily be expanded and manipulated
in vitro, respond to microbial infections in vivo and can be exploited for novel tumor
immunotherapies. We here review findings that suggest that Vc9/Vd2 T cells, and possibly other unconventional
human T cells, play an important role in bridging innate and adaptive immunity by promoting
the activation and differentiation of various types of antigen-presenting cells (APCs) and even turning
into APCs themselves, and thereby pave the way for antigen-specific effector responses and long-term
immunological memory. Although the direct physiological relevance for most of these mechanisms still
needs to be demonstrated in vivo, these findings may have implications for novel therapies, diagnostic
tests and vaccines
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Grant Number
Science Foundation Ireland (SFI)
Author's Homepage:
http://people.tcd.ie/dohertdeDescription:
PUBLISHED
Author: Doherty, Derek
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Series/Report no:
Cellular Immunology296
1
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Full text availableKeywords:
human T cellsDOI:
http://dx.doi.org/10.1016/j.cellimm.2015.01.008Metadata
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