Oncogene-induced autophagy and the Goldilocks principle
Citation:
Martin, S.J., Oncogene-induced autophagy and the Goldilocks principle, Autophagy, 7, 8, 2011, 922-923Download Item:
auto%2E7%2E8%2E15821.pdf (PDF) 448.1Kb
Abstract:
Although several oncogenes enhance
autophagic flux, the molecular
mechanism and consequences of onco
-
gene-induced autophagy remain to be
clarified. We have recently shown that
expression of oncogenic H-Ras
V12
pro
-
motes autophagy through upregulation
of Beclin 1 and the BH3-only protein
Noxa. H-Ras-expressing cells undergo
autophagic cell death as a result of Noxa-
mediated displacement of Mcl-1 and
Bcl-x
L
from Beclin 1. Oncogenic H-Ras-
induced death is attenuated through
knockdown of
BECLIN 1
,
ATG5
or
ATG7
, or through overexpression of
Mcl-1, Bcl-2, Bcl-x
L
and their close rela
-
tives. T
Sponsor
Grant Number
Science Foundation Ireland (SFI)
08/IN.1/B2
Author's Homepage:
http://people.tcd.ie/martinsjDescription:
PUBLISHED
Author: MARTIN, SEAMUS
Type of material:
Journal ArticleCollections:
Series/Report no:
Autophagy7
8
Availability:
Full text availableKeywords:
autophagic fluxLicences: