The homeodomain transcription factor Hb9 controls axon guidance in Drosophila through the regulation of Robo receptors.
Citation:
Santiago C, Labrador JP, Bashaw GJ, The homeodomain transcription factor Hb9 controls axon guidance in Drosophila through the regulation of Robo receptors., Cell Reports, 7, 1, 2014, 153-65Download Item:
Abstract:
Transcription factors establish neural diversity and
wiring specificity; however, how they orchestrate
changes in cell morphology remains poorly under-
stood. The
Drosophila
Roundabout (Robo) receptors
regulate connectivity in the CNS, but how their
precise expression domains are established is un-
known. Here, we show that the homeodomain tran-
scription factor Hb9 acts upstream of Robo2 and
Robo3 to regulate axon guidance in the
Drosophila
embryo. In ventrally projecting motor neurons,
hb9
is required for
robo2
expression, and restoring
Robo2 activity in
hb9
mutants rescues motor axon
defects. Hb9 requires its conserved repressor
domain and functions in parallel with Nkx6 to regu-
late
robo2
. Moreover,
hb9
can regulate the medio-
lateral position of axons through
robo2
and
robo3
,
and restoring
robo3
expression in
hb9
mutants res-
cues the lateral position defects of a subset of neu-
rons. Altogether, these data identify Robo2 and
Robo3 as key effecto
Author's Homepage:
http://people.tcd.ie/labradojDescription:
PUBLISHED
Author: Labrador, Juan
Type of material:
Journal ArticleCollections
Series/Report no:
Cell Reports7
1
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Full text availableKeywords:
Transcription factorsDOI:
http://dx.doi.org/10.1016/j.celrep.2014.02.037ISSN:
2211-1247Metadata
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