Prognostic factors of 2-year outcomes of patients with comorbid bipolar disorder or depression with alcohol dependence: Importance of early abstinence
Citation:
Farren,Conor Kevin C.K., Snee,Laura L., Daly,Pamela P., McElroy,Sharon S., Prognostic factors of 2-year outcomes of patients with comorbid bipolar disorder or depression with alcohol dependence: Importance of early abstinence, Alcohol and Alcoholism, 48, 1, 2013, 93-98Download Item:
Abstract:
Aims:
To investigate the prognostic factors that determine 2-year outcomes in a group of alcohol-dependent patients
with depression or bipolar disorder who were treated in an intensive 4-week inpatient programme.
Methods:
This was a longitudinal
study of an inpatient treatment cohort of dual affective disorder and alcohol-dependent patients, in Dublin, Ireland. Measurements
included baseline demographics with follow-up measurements at discharge, 3 months, 6 months and 2 years after treatment, includ-
ing alcohol consumption, depression, mania/elation, anxiety, craving, drug use and sample blood tests. Factor and regression analysis
of multiple variables was carried out to predict outcomes.
Results:
A total of 189 participants with alcohol dependence and co-
morbid depression (
n
= 101) or bipolar disorder (
n
= 88) were followed over 2 years after discharge from treatment. Retention rate
was 76% over 2 years. Early abstinence (at 6 months) predicted better abstinence overall at 2 years; and bipolar alcoholics had a
better outcome in drinks per drinking day than depressed alcoholics at 2 years. Younger participants (age 18
–
30 years) did relatively
worse than middle-age (30
–
50 years) and older (51 + years) participants in measures of abstinence and number of drinks per drinking
day at 2 years; and females did better than males in number of drinks per drinking day at 2 years.
Conclusion:
Dual diagnosis of
alcohol dependence and depression or bipolar disorder may be treated together with intensive intervention and follow-up, and
various prognostic factors including early abstinence emerge over time that influence outcomes over 2 years
Author's Homepage:
http://people.tcd.ie/cfarrenDescription:
PUBLISHED
Author: FARREN, CONOR
Type of material:
Journal ArticleCollections
Series/Report no:
Alcohol and Alcoholism48
1
Availability:
Full text availableKeywords:
drinksDOI:
http://dx.doi.org/10.1093/alcalc/ags112ISSN:
07350414Metadata
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