dc.contributor.author | ANWYL, ROGER | en |
dc.date.accessioned | 2014-12-19T15:08:39Z | |
dc.date.available | 2014-12-19T15:08:39Z | |
dc.date.issued | 2013 | en |
dc.date.submitted | 2013 | en |
dc.identifier.citation | Li F, Chen X, Wang F, Xu S, Chang L, Anwyl R, Wang Q, Chronic pre-treatment with memantine prevents amyloid-beta protein-mediated long-term potentiation disruption., Neural regeneration research, 8, 1, 2013, 49-55 | en |
dc.identifier.issn | 1673-5374 | en |
dc.identifier.other | Y | en |
dc.identifier.uri | http://hdl.handle.net/2262/72744 | |
dc.description | PUBLISHED | en |
dc.description.abstract | Previous studies indicate that memantine, a low-affinity N-methyl-D-aspartate receptor antagonist, exerted acute protective effects against amyloid-β protein-induced neurotoxicity. In the present study, the chronic effects and mechanisms of memantine were investigated further using electrophysiological methods. The results showed that 7-day intraperitoneal application of memantine, at doses of 5 mg/kg or 20 mg/kg, did not alter hippocampal long-term potentiation induction in rats, while 40 mg/kg memantine presented potent long-term potentiation inhibition. Then further in vitro studys were carried out in 5 mg/kg and 20 mg/kg memantine treated rats. We found that 20 mg/kg memantine attenuated the potent long-term potentiation inhibition caused by exposure to amyloid-β protein in the dentate gyrus in vitro. These findings are the first to demonstrate the antagonizing effect of long-term systematic treatment of memantine against amyloid-β protein triggered long-term potentiation inhibition to improve synaptic plasticity. | en |
dc.format.extent | 49-55 | en |
dc.language.iso | en | en |
dc.relation.ispartofseries | Neural regeneration research | en |
dc.relation.ispartofseries | 8 | en |
dc.relation.ispartofseries | 1 | en |
dc.rights | Y | en |
dc.subject | Physiology | en |
dc.title | Chronic pre-treatment with memantine prevents amyloid-beta protein-mediated long-term potentiation disruption. | en |
dc.type | Journal Article | en |
dc.type.supercollection | scholarly_publications | en |
dc.type.supercollection | refereed_publications | en |
dc.identifier.peoplefinderurl | http://people.tcd.ie/ranwyl | en |
dc.identifier.rssinternalid | 98454 | en |
dc.identifier.doi | http://dx.doi.org/10.3969/j.issn.1673-5374.2013.01.006 | en |
dc.rights.ecaccessrights | openAccess | |