A nested case-control study of adjuvant hormonal therapy persistence and compliance, and early breast cancer recurrence in women with stage I-III breast cancer
Citation:
Barron TI, Cahir C, Sharp L, Bennett K, A nested case-control study of adjuvant hormonal therapy persistence and compliance, and early breast cancer recurrence in women with stage I-III breast cancer, British Journal of Cancer, 109, 6, 2013, 1513 - 1521Download Item:
Abstract:
Background:
Non-persistence and non-compliance are common in women prescribed hormonal therapy for breast cancer, but little is known about their influence on recurrence.
Methods:
A nested case–control study of associations between hormonal therapy non-persistence and non-compliance and the risk of early recurrence in women with stage I–III breast cancer was undertaken. Cases, defined as women with a breast cancer recurrence within 4 years of hormonal therapy initiation, were matched to controls (1 : 5) by tumour stage and age. Conditional logistic regression was used to examine associations between early recurrence and hormonal therapy non-persistence and non-compliance.
Results:
Ninety-four women with breast cancer recurrence were matched to 458 controls. Women who were non-persistent ([gt-or-equal, slanted]180 days without hormonal therapy) had a significantly increased adjusted recurrence odds ratio (OR) of 2.88 (95%CI 1.11, 7.46) compared with persistent women. There was no significant association between low compliance (OR 1.30; 95% CI 0.74, 2.30) and breast cancer recurrence.
Conclusion:
Hormonal therapy non-persistence is associated with a significantly higher risk of early recurrence in women with stage I–III oestrogen receptor (ER)-positive breast cancer. This finding is consistent with results from randomized studies of hormonal therapy treatment duration and suggests that interventions to target modifiable risk factors for non-persistence are required.
Author's Homepage:
http://people.tcd.ie/bennettkDescription:
PUBLISHED
Author: BENNETT, KATHLEEN
Type of material:
Journal ArticleSeries/Report no:
British Journal of Cancer109
6
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Full text availableKeywords:
breast cancerMetadata
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