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dc.contributor.authorRAMASWAMI, MANIen
dc.date.accessioned2014-12-01T11:38:40Z
dc.date.available2014-12-01T11:38:40Z
dc.date.issued2013en
dc.date.submitted2013en
dc.identifier.citationRamaswami, M., Taylor, J.P., Parker, R, Altered ribostasis: RNA-protein granules in degenerative disorders, Cell, 154, 4, 2013, 727-736en
dc.identifier.otherYen
dc.identifier.urihttp://hdl.handle.net/2262/72317
dc.descriptionPUBLISHEDen
dc.description.abstractThe molecular processes that contribute to degenerative diseases are not well understood. Recent observations suggest that some degenerative diseases are promoted by the accumulation of nuclear or cytoplasmic RNA-protein (RNP) aggregates, which can be related to endogenous RNP granules. RNP aggregates arise commonly in degenerative diseases because RNA-binding proteins commonly self-assemble, in part through prion-like domains, which can form self-propagating amyloids. RNP aggregates may be toxic due to multiple perturbations of posttranscriptional control, thereby disrupting the normal "ribostasis" of the cell. This suggests that understanding and modulating RNP assembly or clearance may be effective approaches to developing therapies for these diseases.en
dc.format.extent727-736en
dc.language.isoenen
dc.relation.ispartofseriesCellen
dc.relation.ispartofseries154en
dc.relation.ispartofseries4en
dc.rightsYen
dc.subjectGeneticsen
dc.titleAltered ribostasis: RNA-protein granules in degenerative disordersen
dc.typeJournal Articleen
dc.contributor.sponsorNational Institutes of Health (NIH)en
dc.contributor.sponsorNational Institutes of Health (NIH)en
dc.type.supercollectionscholarly_publicationsen
dc.type.supercollectionrefereed_publicationsen
dc.identifier.peoplefinderurlhttp://people.tcd.ie/ramaswamen
dc.identifier.rssinternalid95083en
dc.identifier.doihttp://dx.doi.org/10.1016/j.cell.2013.07.038en
dc.rights.ecaccessrightsopenAccess
dc.contributor.sponsorGrantNumberNS053825en
dc.contributor.sponsorGrantNumberGM045443en


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