An alternative method for Frailty Index cut-off points to define frailty categories.
Item Type:Journal Article
Citation:Romero-Ortuno R, An alternative method for Frailty Index cut-off points to define frailty categories., European geriatric medicine, 4, 5, 2013
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PURPOSE: the Frailty Index (FI) is a popular operationalization of frailty. FI cut-off points have been proposed to define, regardless of age, frailty categories with increasing risk. Here, an alternative method is described that takes age into account. SUBJECTS AND METHODS: 29,905 participants aged ≥ 50 from the first wave of the Survey of Health, Ageing and Retirement in Europe. The mean follow-up for mortality was 2.4 years. Curve estimation procedures were carried out between age and a FI, and 50% Confidence Intervals (CI) for the regression mean were derived. As opposed to the usual method (FI ≤ 0.08: non-frail; FI ≥ 0.25: frail; rest: pre-frail), the alternative method defines as 'fit for their age' those with a FI below the lower 50% CI; 'frail for their age' those with a FI above the upper 50% CI; the rest as 'average for their age'. Using both methods, the prevalence of the frailty categories and their associated mortality rates were compared for each age group. RESULTS: The best fit between age the FI was by cubic regression (R 2 = 0.174, P < 0.001). Among those in their 50s, 5% were frail by the usual method (mortality: 5%) and 14% by the alternative (mortality: 2%). Among those in their 90s, 64% were frail by the usual method (mortality: 43%) and 41% by the alternative (mortality: 48%). CONCLUSION: the alternative method may be more sensitive in younger ages and more specific in older ages. This may have implications for population screening.
Author: ROMERO-ORTUNO, ROMAN
Type of material:Journal Article
Series/Report no:European geriatric medicine
Availability:Full text available
Keywords:Validation studies, Severity of Illness Index, Mortality, Longitudinal Study, Frail Elderly