Clinical Medicine: Recent submissions
Now showing items 6-25 of 949
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Profiling Serum and Tissue Biomarkers of Vedolizumab Therapy Response in Inflammatory Bowel Disease.
(Trinity College Dublin. School of Medicine. Discipline of Clinical Medicine, 2024)Introduction: Vedolizumab (VDZ) is a novel biologic agent proven effective for Inflammatory bowel disease (IBD), however, a significant proportion of patients do not respond to VZD treatment Aims: This thesis evaluates ... -
Exploring the effects of time-restricted eating as a novel intervention in patients with polycystic ovarian syndrome
(Trinity College Dublin. School of Medicine. Discipline of Clinical Medicine, 2024)Introduction: Polycystic ovarian syndrome (PCOS) is associated with hyperinsulinemia, insulin resistance and a high lifetime risk of developing type-2 diabetes mellitus. While many dietary interventions have been tested ... -
The Role of EUS and Proteomic Analysis in the Management and Surveillance of Pancreatic Cystic Lesions
(Trinity College Dublin. School of Medicine. Discipline of Clinical Medicine, 2024)Introduction Pancreatic cystic lesions (PCL) can be precursors to pancreatic cancer. The incidence of PCL are increasing worldwide with increased patient age and reliance on cross sectional imaging. However, not all PCL ... -
Network Analysis in Amyotrophic Lateral Sclerosis during Voluntary Motor Task: Neurophysiological Biomarkers of Disrupted Cortical Connections
(Trinity College Dublin. School of Medicine. Discipline of Clinical Medicine, 2024)Amyotrophic lateral sclerosis (ALS) is a fatal progressive neurodegenerative disease that causes degeneration of both upper and lower motor neurons primarily affecting the motor system, but individual people with ALS show ... -
Characterisation of a mutant mouse model of spontaneous atopic dermatitis
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Clinical Medicine, 2017)Atopy is Immunoglobulin-E sensitisation to “allergens” such as pollen and food. Atopic dermatitis is a pruritic eczematous dermatitis associated with an early onset in infants. Atopic dermatitis has a complex pathology and ... -
Characterising the progression of haemophilic arthropathy in knee joints of a novel mouse model of severe haemophilia A
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Neuroimaging correlates of disability in Motor Neuron Disease
(Trinity College Dublin. School of Medicine. Discipline of Clinical Medicine, 2024)Motor neuron diseases (MND) clinically present with a wide variety of motor and extra-motor symptoms. However, the pathological correlates of such symptom manifestation and their progression is poorly understood. In the ... -
The role of canonical and non-canonical inflammasomes in a model of oxidative stress-induced retinal degeneration
(Trinity College Dublin. School of Medicine. Discipline of Clinical Medicine, 2024)Retinal degenerative diseases like age-related macular degeneration (AMD) are a leading cause of visual impairment. Oxidative stress is known to be important in the pathogenesis of AMD, and oxidative-stress induced retinal ... -
Supportive care: the "keystone" of modern oncology practice
(2023)The Multinational Association of Supportive Care in Cancer (MASCC) defines supportive care as "the prevention and management of the adverse effects of cancer and its treatment. This includes management of physical and ... -
Taste disturbance in patients with advanced cancer: a scoping review of clinical features and complications
(2023)Purpose: The purpose of this scoping review is to appraise the published literature on taste disturbance in patients with advanced cancer, with the specific objectives being to determine its prevalence, clinical features ... -
Circadian rhythm disorders in patients with advanced cancer: a scoping review
(2023)Circadian rhythms can be demonstrated in several biomarkers and behavioural activities, with rhythmical patterns occurring roughly over a 24-h period. Circadian disorders occur in patients with cancer and may be associated ... -
Challenges to delivering evidence-based palliative medicine
(2023)Established as a medical specialty in 1987, palliative medicine approaches middle age facing existential questions of identity, purpose and vision. Time has weakened strong foundations laid by Dame Cicely Saunders in ... -
Xerostomia in patients with advanced cancer: a scoping review of clinical features and complications
(2023)Background: The aim of this project was to review the literature on dry mouth / xerostomia in patients with advanced cancer, with the objectives being to determine its prevalence, clinical features, and complications. Methods: ... -
Vital signs in palliative care: a scoping review
(2023)Vital signs are routinely measured in secondary healthcare settings and can be used to detect clinical problems, guide treatment, and monitor response to treatment. Vital signs are less frequently measured in palliative ... -
Validation of a French version of the Breakthrough Pain Assessment Tool in cancer patients: factorial structure, reliability and responsiveness
(2023)Objective: Breakthrough cancer pain should be properly assessed for better-personalized treatment plan. The Breakthrough Pain Assessment Tool is a 14-item tool validated in English developed for this purpose; no French ... -
International e-Delphi consensus recommendations for the assessment and diagnosis of circadian rest-activity rhythm disorders (CARDs) in patients with cancer
(2023)Purpose: Circadian rest-Activity Rhythm Disorders (CARDs) are common in patients with cancer, particularly in advanced disease. CARDs are associated with increased symptom burden, poorer quality of life, and shorter survival. ... -
Specialist palliative for patients with cancer: more than end-of-life care
(2023)Palliative care has traditionally focused on end-of-life care for patients with advanced cancer. This has since expanded to include symptom management and quality-of-life improvement from the moment of cancer diagnosis. ... -
Multinational Association of Supportive Care in Cancer (MASCC) expert opinion / guidance on the use of clinically-assisted hydration in patients with advanced cancer
(2024)Purpose: The provision of clinically assisted hydration (CAH) in patients with advanced cancer is controversial, and there is a paucity of specific guidance and so a diversity in clinical practice. Consequently, the ... -
A Cross-Disease Study Investigating the Phenotypic and Functional Heterogeneity in Neutrophil Subsets
(Trinity College Dublin. School of Medicine. Discipline of Clinical Medicine, 2024)Neutrophils play a critical role in the innate immune response. They are the most abundant leukocytes in humans and are the first line of defence against invading microorganisms; growing evidence in the last decade has ... -
Characteristics and Outcomes of Older Adults Following Distal Forearm Fracture
(Trinity College Dublin. School of Medicine. Discipline of Clinical Medicine, 2024)Introduction Osteoporosis and fragility fractures pose a serious public health challenge in our ageing society. Systems are being developed in Ireland and internationally to provide, coordinated and comprehensive assessments ...