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Enrichment of circulating head and neck tumour cells using spiral microfluidic technology
(2017)
Whilst locoregional control of head and neck cancers (HNCs) has improved over the last four decades, long-term survival has remained largely unchanged. A possible reason for this is that the rate of distant metastasis has ...
July 2017 ENCALS statement on edaravone
(2017)
Neurologists of the ENCALS centers throughout Europe have discussed the potential of edaravone as anew therapy for amyotrophic lateral sclerosis (ALS,Motor Neuron Disease, MND) at the ENCALS meeting, 18–20 May 2017, in ...
The protective association of endogenous immunoglobulins against sepsis mortality is restricted to patients with moderate organ failure
(Springer Paris, 2017)
Background
Pre-evaluation of endogenous immunoglobulin levels is a potential strategy to improve the results of intravenous immunoglobulins in sepsis, but more work has to be done to identify those patients who could ...
Vaccination as a means of disease prevention in HIV infected individuals; successes, challenges & opportunities
(Trinity College Dublin. School of Medicine. Discipline of Clinical Medicine, 2017)
This thesis is structured to systemically assess susceptibility to vaccine preventable infections in HIV-infected adults, to investigate effectiveness of an integrated vaccine programme as a model of care for vaccine ...
Prevalence of frailty among community dwelling older adults in receipt of low level home support: a cross-sectional analysis of the North Dublin Cohort
(2017)
Background:
There is increasing demand for formal government funded home help services to support community-dwelling older people in Ireland, yet limited information exists on the health profiles of this group, especially ...
Amyotrophic lateral sclerosis patient iPSC-derived astrocytes impair autophagy via non-cell autonomous mechanisms
(BMC, 2017)
Amyotrophic lateral sclerosis, a devastating neurodegenerative disease, is characterized by the progressive loss of motor neurons and the accumulation of misfolded protein aggregates. The latter suggests impaired proteostasis ...
Examining the breadth and burden of chronic kidney disease in community-dwelling older adults
(Trinity College Dublin. School of Medicine. Discipline of Clinical Medicine, 2017)
Introduction: Chronic kidney disease (CKD), characterised by reductions in glomerular filtration rate (GFR), is associated with premature mortality and end stage kidney disease. Older adults have the highest prevalence of ...