Browsing Clinical Medicine by Sponsor "Irish Research Council (IRC)"
Now showing items 1-9 of 9
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Comparing the Effects of Intracellular and Extracellular Magnetic Hyperthermia on the Viability of BxPC-3 Cells
(2020)Magnetic hyperthermia involves the use of iron oxide nanoparticles to generate heat in tumours following stimulation with alternating magnetic fields. In recent times, this treatment has undergone numerous clinical trials ... -
A Cross-Disease Study Investigating the Phenotypic and Functional Heterogeneity in Neutrophil Subsets
(Trinity College Dublin. School of Medicine. Discipline of Clinical Medicine, 2024)Neutrophils play a critical role in the innate immune response. They are the most abundant leukocytes in humans and are the first line of defence against invading microorganisms; growing evidence in the last decade has ... -
Development of an Objective Assessment of the Cognitive, Posturographic, and Electrophysiological Phenotype of the Fragile X Premutation, and analysis of their contribution to Postural Instability.
(Trinity College Dublin. School of Medicine. Discipline of Clinical Medicine, 2021)The Fragile X Premutation is a complex genetic anomaly which affects one in 260 females and 400 males and results in a broad range of symptoms and distinct conditions. The premutation phenotype involves cognitive and motor ... -
Development of an optimised subharmonic dynamic contrast-enhanced ultrasound imaging technique for liver cancer
(Trinity College Dublin. School of Medicine. Discipline of Clinical Medicine, 2018)Dynamic Contrast-Enhanced Ultrasound (DCEUS) using ultrasound contrast agents (UCA) is a non-invasive method of imaging the microvasculature, typically employing harmonic imaging. Subharmonic imaging (SHI) detects signals ... -
Human Neurodegeneration: A Spectral EEG and TMS based Approach in Amyotrophic Lateral Sclerosis
(Trinity College Dublin. School of Medicine. Discipline of Clinical Medicine, 2021)Amyotrophic lateral sclerosis (ALS) is defined by the neurodegeneration of upper and lower motor neurons of the corticospinal tract, resulting in progressive, terminal and incurable decline in movement, speech and swallowing ... -
Hungry for More: Measuring Metabolomic Responses in ANCA-Activated Monocytes
(Trinity College Dublin. School of Medicine. Discipline of Clinical Medicine, 2022)Immunometabolism examines the links between immune cell function and their metabolism. Advances in liquid chromatography mass spectrometry (LC-MS) technologies have uncovered unique insights into cellular metabolomics. ... -
Macrophages are critical drivers of synovial inflammation in Rheumatoid Arthritis
(Trinity College Dublin. School of Medicine. Discipline of Clinical Medicine, 2020)Macrophages are an exquisitely plastic pool of innate cells critically involved in directing the immune response in RA. Upon entry into the synovium, peripheral blood monocytes differentiate into the dichotomous M1 ... -
Network Analysis in Amyotrophic Lateral Sclerosis during Voluntary Motor Task: Neurophysiological Biomarkers of Disrupted Cortical Connections
(Trinity College Dublin. School of Medicine. Discipline of Clinical Medicine, 2024)Amyotrophic lateral sclerosis (ALS) is a fatal progressive neurodegenerative disease that causes degeneration of both upper and lower motor neurons primarily affecting the motor system, but individual people with ALS show ... -
A Precision Medicine Approach to Dosing and Management of Continuous Renal Replacement Therapy for Acute Kidney Injury
(Trinity College Dublin. School of Medicine. Discipline of Clinical Medicine, 2020)Background: Despite decades of research, the mainstay of treatment for severe acute kidney injury (AKI) in the critical care setting remains renal replacement therapy in the form of dialysis. Continuous renal replacement ...