Browsing Clinical Medicine by Author "Reynolds, John"
Now showing items 1-3 of 3
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The Development and Application of a Novel Method for the Quantification of Prebeta-1 HDL in Plasma
O'CONNOR, PATRICIA MARIE-THERESE (Trinity College Dublin. School of Medicine. Discipline of Clinical Medicine, 2019)Prebeta-1 HDL was one of the distinct molecular subspecies of HDL identified in the mid to late eighties . It is, now recognised as having a pivotal role in reverse cholesterol transport accounting for up to 90% of cholesterol ... -
Differential expression profiles of oxidative stress levels, 8-oxo-dG and 4-HNE, in Barrett?s esophagus compared to esophageal adenocarcinoma
Phelan, James; Reynolds, John; Ravi, Narayanasamy (2019)Barrett’s esophagus (BE), a chronic inflammatory condition, is the leading risk factor for esophageal adenocarcinoma (EAC). In inflammation to cancer pathways, oxidative stress profiles have been linked to cancer progression. ... -
siRNA Library Screening Identifies a Druggable Immune-Signature Driving Esophageal Adenocarcinoma Cell Growth
Reynolds, John; Long, Aideen; Duggan, Shane P.; Garry, Catherine; Behan, Fiona; Phipps, Sinead; Kudo, Hiromi; Kirca, Murat; Zaheer, Abdul; McGarrigle, Sarah; Goldin, Robert; Kalloger, Steve E.; Schaeffer, David F.; Strid, Jessica; Kelleher, Dermot (2018)This study de fi nes immune-associated factors supportive of esophageal adenocarcinoma cell growth through small interfering RNA screening and pathologic and functional studies. Fostamatinib R788, targeting Janus ...