Browsing Clinical Medicine by Author "Pender, Niall"
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ALS-specific cognitive and behavior changes associated with advancing disease stage in ALS
Hardiman, Orla; Pender, Niall (2018)Objective: To elucidate the relationship between disease stage in amyotrophic lateral sclerosis (ALS), as measured with the King's Clinical Staging System, and cognitive and behavioral change, measured with the Edinburgh ... -
Building a supportive framework for brain research in Ireland: Inaugural position paper of the Irish Brain Council
Hardiman, Orla; Mitchell, Kevin; Pender, Niall (Wiley, 2019)The Irish Brain Council is an independent group of organisations which have come together to influence and impact upon brain research in Ireland. The purpose of the Irish Brain Council is to promote ... -
Determining the incidence of familiality in ALS: A study of temporal trends in Ireland from 1994 to 2016
Hardiman, Orla; Mc Laughlin, Russell; Pender, Niall (2018)Objective: To assess temporal trends in familial amyotrophic lateral sclerosis (FALS) incidence rates in an Irish population and to determine factors influencing FALS ascertainment. Methods: Population-based data collected ... -
Measuring reliable change in cognition using the Edinburgh Cognitive and Behavioural ALS Screen (ECAS)
Pender, Niall; Hardiman, Orla (2018)Background: Cognitive impairment affects approximately 50% of people with amyotrophic lateral sclerosis (ALS). Research has indicated that impairment may worsen with disease progression. The Edinburgh Cognitive and Behavioural ... -
Needs of informal caregivers across the caregiving course in amyotrophic lateral sclerosis: a qualitative analysis
Pender, Niall; Hardiman, Orla; Galvin, Miriam (2018)Objectives: Amyotrophic lateral sclerosis (ALS), also known as motor neuron disease (MND), is a debilitating terminal condition. Informal caregivers are key figures in ALS care provision. The physical, psychological and ... -
Neurophysiological markers of network dysfunction in neurodegenerative diseases
Bede, Peter; Hardiman, Orla; Pender, Niall (Elsevier, 2019)There is strong clinical, imaging and pathological evidence that neurodegeneration is associated with altered brain connectivity. While functional imaging (fMRI) can detect resting and activated states of metabolic activity, ...