Browsing Clinical Medicine by Author "Kane, David"
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Comprehensive assessment of rheumatoid arthritis susceptibility loci in a large psoriatic arthritis cohort
Mc Manus, Ross; Kane, David (2012)Objective: A number of rheumatoid arthritis (RA) susceptibility genes have been identified in recent years. Given the overlap in phenotypic expression of synovial joint inflammation between RA and psoriatic arthritis (PsA), ... -
Confirmation of TNIP1 and IL23A as susceptibility loci for psoriatic arthritis
Kane, David; Mc Manus, Ross; Bowes, John; Orozco, Gisela; Flynn, Edward; Ho, Pauline; Brier, Rasha; Marzo-Ortega, Helena; Coates, Laura; Ryan, Anthony W.; Korendowych, Eleanor; McHugh, Neil; Fitzgerald, Oliver; Packham, Jonathan; Morgan, Ann W.; Bruce, Ian N.; Barton, Anne (2011)Objectives: To investigate a shared genetic aetiology for skin involvement in psoriasis and psoriatic arthritis (PsA) by genotyping single-nucleotide polymorphisms (SNPs), reported to be associated in genome-wide ... -
Cross phenotype association mapping of the MHC identifies genetic variants that differentiate psoriatic arthritis from psoriasis
Mc Manus, Ross; Kane, David (2017)Objectives: Psoriatic arthritis (PsA) is a chronic inflammatory arthritis, with a strong heritable component, affecting patients with psoriasis. Here we attempt to identify genetic variants within the major histocompatibility ... -
Dense genotyping of immune-related susceptibility loci reveals new insights into the genetics of psoriatic arthritis
Mc Manus, Ross; Kane, David (2015)Poriatic arthritis (PsA) is a chronic inflammatory arthritis associated with psoriasis and, despite the larger estimated heritability for PsA, the majority of genetic susceptibility loci identified to date are shared ... -
Evidence to support IL-13 as a risk locus for psoriatic arthritis but not psoriasis vulgaris.
Mc Manus, Ross; Kane, David (2011)OBJECTIVE: /st> There is great interest in the identification of genetic factors that differentiate psoriatic arthritis (PsA) from psoriasis vulgaris (PsV), as such discoveries could lead to the identification of distinct ... -
PTPN22 is associated with susceptibility to psoriatic arthritis but not psoriasis: evidence for a further PsA-specific risk locus
Mc Manus, Ross; Kane, David (2015)Objectives: Psoriatic arthritis (PsA) is a chronic inflammatory arthritis associated with psoriasis; it has a higher estimated genetic component than psoriasis alone, however most genetic susceptibility loci identified for ... -
Replication of a distinct psoriatic arthritis risk variant at the IL23R locus
Mc Manus, Ross; Kane, David (2016)Psoriatic arthritis (PsA) is a chronic inflammatory arthritis associated with the presence of psoriasis. Although the majority of PsA genetic risk loci identified also confer risk for psoriasis, the difference in ... -
Variants in linkage disequilibrium with the late cornified envelope gene cluster deletion are associated with susceptibility to psoriatic arthritis
Mc Manus, Ross; Kane, David (2010)Objective: A common deletion mapping to the psoriasis susceptibility locus 4 on chromosome 1q21, encompassing two genes of the late cornified envelope (LCE) gene cluster, has been associated with an increased risk of ...