Browsing Clinical Medicine by Author "Gallagher, Muriel"
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Studies on methotrexate cytotoxicity and apoptosis in human B-lymphocyte cell lines : with emphasis on 5,10-methylenetetrahydrofolate reductase 677C→T genotype and folate status
Gallagher, Muriel (Trinity College (Dublin, Ireland). School of Medicine. Discipline of Clinical Medicine, 2011)Methotrexate (Mtx) is an antifolate drug which is widely used in treatment of cancer and of autoimmune and inflammatory conditions. The main mechanism by which Mtx operates is inhibition of dihydrofolate reductase (DHFR), ...