Browsing Clinical Medicine by Author "Doherty, Derek"
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Adaptive and Innate TH1 and TH17 Responses in Elderly Hospitalised Patients with Infection and Sepsis
Coakley, John Davis (Trinity College Dublin. School of Medicine. Discipline of Clinical Medicine, 2021)Introduction: Sepsis carries a significant burden to health care. Almost a third of ICU patients have sepsis on admission or develop it during their admission. Sepsis carries a high mortality and affects all age groups ... -
Hepatitis C virus targets the T cell secretory machinery as a mechanism of immune evasion.
Long, Aideen; Petrovic, Danijela; Stamataki, Zania; Dempsey, Eugene; Golden-Mason, Lucy; Freeley, Michael; Doherty, Derek; Prichard, David; Keogh, Catherine; Conroy, Jennifer; Mitchell, Siobhan; Volkov, Yuri; McKeating, Jane A.; O'Farrelly, Cliona; Kelleher, Dermot (2011)T cell activation and the resultant production of interleukin (IL-2) is a central response of the adaptive immune system to pathogens, such as hepatitis C virus (HCV). HCV uses sev- eral mechanisms to evade both the ... -
Post-operative infection and sepsis in humans is associated with deficient gene expression of Yc cytokines and their apoptosis mediators.
Ryan, Thomas; Doherty, Derek; Kelleher, Dermot; Mc Manus, Ross (2011)INTRODUCTION: Lymphocyte homeostasis is dependent on the ?c cytokines. We hypothesised that sepsis in humans is associated with differential gene expression of the ?c cytokines and their associated apoptosis mediators. ...