Browsing Clinical Medicine by Author "Baird, Anne-Marie"
Now showing items 1-4 of 4
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Activation and cleavage of SASH1 by caspase-3 mediates an apoptotic response
O'Byrne, Ken; Gately, Kathy; Baird, Anne-Marie (2016)Apoptosis is a highly regulated cellular process that functions to remove undesired cells from multicellular organisms. This pathway is often disrupted in cancer, providing tumours with a mechanism to avoid cell death and ... -
Development of EphA2 siRNA-loaded lipid nanoparticles and combination with a small-molecule histone demethylase inhibitor in prostate cancer cells and tumor spheroids.
Gray, Steven; Oner-Bozkurt, Ezgi; Finn, Stephen; Baird, Anne-Marie (2021)Background siRNAs hold a great potential for cancer therapy, however, poor stability in body fluids and low cellular uptake limit their use in the clinic. To enhance the bioavailability of siRNAs in tumors, novel, safe, ... -
Targeting nuclear factor-kappa B to overcome resistance to chemotherapy.
O'Byrne, Ken; Gately, Kathy; Barr, Martin; Baird, Anne-Marie (2013)Intrinsic or acquired resistance to chemotherapeutic agents is a common phenomenon and a major challenge in the treatment of cancer patients. Chemoresistance is defined by a complex network of factors including multi-drug ... -
The role of inflammatory mediators and hypoxia in lung carcinogenesis
Baird, Anne-Marie (Trinity College (Dublin, Ireland). School of Medicine. Discipline of Clinical Medicine, 2009)Lung cancer is the most common cause of cancer related death in Ireland. While treatment options and long term survival have increased for other cancer types, lung cancer lags behind in both areas, with 5 year survival ...