Browsing Clinical Medicine by Title
Now showing items 910-929 of 947
-
Unconjugated secondary bile acids activate the unfolded protein response and induce golgi fragmentation via a src-kinase-dependant mechanism
(2017)Bile acids are components of gastro-duodenal refluxate and regarded as causative agents in oesophageal disease but the precise mechanisms are unknown. Here we demonstrate that a specific subset of physiological bile acids ... -
Uncoupling protein 2 polymorphisms as risk factors for NTDs
(2009)Both environmental and genetic factors are involved in the etiology of neural tube defects (NTDs). Inadequate folate intake and obesity are important environmental risk factors. Several folate-related genetic variants have ... -
Undernutrition in inactive and mildly active Crohn's Disease : an unrecognised problem?
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Clinical Medicine, 2009)Crohn's disease (CD), the incidence of which is increasing worldwide, is a chronic transmural inflammatory disease that can affect any part of the gastrointestinal tract. It follows a relapsing remitting course and results ... -
Understanding and exploiting the effect of tuberculosis antimicrobials on host mitochondrial function and bioenergetics
(2020)Almost 140 years after its discovery, tuberculosis remains the leading infectious cause of death globally. For half a century, patients with drug-sensitive and drug-resistant tuberculosis have undergone long, arduous, and ... -
Unequal rates of Y chromosome gene divergence during speciation of the family Ursidae.
(2008)Evolution of the bear family Ursidae is well investigated in terms of morphological, paleontological, and genetic features. However, several phylogenetic ambiguities occur within the subfamily Ursinae (the family Ursidae ... -
Untreated chronic tuberculous salpingitis followed by successful in vitro fertilization conception and congenital tuberculosis
(2015)Female reproductive tract tuberculosis is rarein the developed world and its diagnosis ischallenging. However, this case illustrates theimportance of including female reproductivetract tuberculosis in the differential for ... -
Untreated Chronic Tuberculous Salpingitis followed by successful IVF Conception and Congenital Tuberculosis.
(2015)Female reproductive tract tuberculosis is rare in the developed world and its diagnosis is challenging. However, this case illustrates the importance of including female reproductive tract tuberculosis in the differential ... -
Ursodeoxycholic acid : a molecular modulator of the inflammation-carcinoma sequence in the oesophagus?
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Clinical Medicine, 2012)Gastro-oesophageal reflux disease (GORD) is a prevalent disease, affecting up to 20% of the western population. In up to 10% of these patients Barrett’s Oesophagus (BO) will exist. This nietaplastic epithelium carries a ... -
Ursodeoxycholic acid attenuates colonic epithelial secretory function.
(2013)Dihydroxy bile acids, such as chenodeoxycholic acid (CDCA), are well known to promote colonic fluid and electrolyte secretion, thereby causing diarrhoea associated with bile acid malabsorption. However, CDCA is rapidly ... -
Using Action Research and Peer Perspectives to Develop Technology That Facilitates Behavioral Change and Self-Management in COPD
(2014)Background. Behavioural change and self-management in patients with chronic illness may help to control symptoms, avoid rehospitalization, enhance quality of life, and decrease mortality and morbidity. Objective. Guided ... -
Vaccination as a means of disease prevention in HIV infected individuals; successes, challenges & opportunities
(Trinity College Dublin. School of Medicine. Discipline of Clinical Medicine, 2017)This thesis is structured to systemically assess susceptibility to vaccine preventable infections in HIV-infected adults, to investigate effectiveness of an integrated vaccine programme as a model of care for vaccine ... -
Validation of a French version of the Breakthrough Pain Assessment Tool in cancer patients: factorial structure, reliability and responsiveness
(2023)Objective: Breakthrough cancer pain should be properly assessed for better-personalized treatment plan. The Breakthrough Pain Assessment Tool is a 14-item tool validated in English developed for this purpose; no French ... -
Validation of the EULAR/ERA-EDTA recommendations for the management of ANCA-associated vasculitis by disease content experts
(2017)The European League Against Rheumatism recommendations for the management of antineutrophil cytoplasmic antibody-associated vasculitis have been recently published. Unique to recommendation development, they were also voted ... -
Validation of two risk prediction models for recurrent falls in the first year after stroke: A prospective cohort study
(2017)Background: several multivariable models have been derived to predict post-stroke falls. These require validation before integration into clinical practice. The aim of this study was to externally validate two prediction ... -
Variants in linkage disequilibrium with the late cornified envelope gene cluster deletion are associated with susceptibility to psoriatic arthritis
(2010)Objective: A common deletion mapping to the psoriasis susceptibility locus 4 on chromosome 1q21, encompassing two genes of the late cornified envelope (LCE) gene cluster, has been associated with an increased risk of ... -
Variation in clinical outcomes and immune consequences following two viral infections
Ageing is associated with increasing rates of ill-health. However, the burden of ill-health is not evenly distributed across ageing populations. The term biological age captures the consequences of ageing more effectively ... -
Vascular biomarkers of cognitive performance in a community-based elderly population: the Dublin Healthy Ageing study.
(2008)BACKGROUND: population studies suggest that cardiovascular risk factors may be associated with cognitive impairment. Epidemiological studies evaluating individual markers of vascular disease as risk factors for cognitive ...
