Browsing Clinical Medicine by Title
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SARM1 Promotes Photoreceptor Degeneration in an Oxidative Stress Model of Retinal Degeneration
(2022)SARM1 (sterile alpha and armadillo motif-containing protein) is a highly conserved Toll/IL-1 Receptor (TIR) adaptor with important roles in mediating immune responses. Studies in the brain have shown that SARM1 plays a ... -
SASH1 mediates sensitivity of breast cancer cells to chloropyramine and is associated with prognosis in breast cancer
(2016)Expression of the SASH1 protein is reduced in a range of human cancers and has been implicated in apoptotic cancer cell death. This study investigated whether increasing SASH1 expression could be a useful therapeutic ... -
Schistosoma "Eggs-Iting" the Host: Granuloma Formation and Egg Excretion.
(2018)Schistosomiasis is a major cause of morbidity in humans invoked by chronic infection with parasitic trematodes of the genus Schistosoma. Schistosomes have a complex life-cycle involving infections of an aquatic snail ... -
The schistosoma granuloma: friend or foe?
(2013)Infection of man with Schistosoma species of trematode parasite causes marked chronic morbidity. Individuals that become infected with Schistosomes may develop a spectrum of pathology ranging from mild cercarial dermatitis ... -
Schistosoma mansoni secretes a chemokine binding protein with anti-inflammatory activity.
(Rockefeller University Press, 2005)The coevolution of humans and infectious agents has exerted selective pressure on the immune system to control potentially lethal infections. Correspondingly, pathogens have evolved with various strategies to modulate and ... -
Schistosoma mansoni worms induce anergy of T cells via selective up-regulation of programmed death ligand 1 on macrophages
(The Journal of Immunology, 2004)Infectious pathogens can selectively stimulate activation or suppression of T cells to facilitate their survival within humans. In this study we demonstrate that the trematode parasite Schistosoma mansoni has evolved with ... -
Screening for vitamin B-12 and folate deficiency in older persons
(American Society for Clinical Nutrition, 2003)Background: Vitamin B-12 deficiency is usually accompanied by elevated concentrations of serum total homocysteine (tHcy) and methylmalonic acid (MMA). Folate deficiency also results in elevated tHcy. Measurement of these ... -
Seasonal variation of serum vitamin D and the effect of vitamin D supplementation in Irish community-dwelling older people.
(2011)BACKGROUND: Ireland is at 53°N, and its population risk of vitamin D deficiency is high. Previous Irish studies suggested a significant seasonality of serum 25-hydroxyvitamin D [25(OH)D] and a beneficial effect of ... -
Sequencing of therapy following first-line afatinib in patients with EGFR mutation-positive non-small cell lung cancer
(Elsevier, 2019)Objectives: With the availability of several epidermal growth factor receptor (EGFR) tyrosine kinase inhibitors (TKIs), sequential therapy could potentially render EGFR mutation-positive non-small cell lung cancer a chronic ... -
Severe dermatitis, multiple allergies, and metabolic wasting syndrome caused by a novel mutation in the N-terminal plakin domain of desmoplakin.
(2015)Background Severe dermatitis, multiple allergies, and metabolic wasting (SAM) syndrome is a recently recognized syndrome caused by mutations in the desmoglein 1 gene (DSG1). To date, only 3 families have been ... -
Severity of Elastase-Induced Emphysema Is Decreased in Tumor Necrosis Factor-α and Interleukin-1β Receptor-Deficient Mice
(2002)A single intratracheal dose of porcine pancreatic elastase, which is cleared from the lung by 24 hours, was administered to wild-type, IL-1β type 1 receptor-deficient, double TNF-α (type 1 and type 2) receptor-deficient, ... -
Shared changes in angiogenic factors across gastrointestinal vascular conditions: A pilot study
(2020)BACKGROUND Neovascularisation is common to a variety of gastrointestinal (GI) disorders with differing aetiologies and presentations; usually affecting adults above 60 years. Shared angiogenic factors modulated by disease ... -
Short term ex-vivo expansion of circulating head and neck tumour cells
(2016)Minimally invasive techniques are required for the identification of head and neck cancer (HNC) patients who are at an increased risk of metastasis, or are not responding to therapy. An approach utilised in other solid ... -
The short-term bioavailabilities of [6S]-5-methyltetrahydrofolate and folic acid are equivalent in men.
(The American Society for Nutritional Sciences, 2004)The natural folate derivative, 5-methyltetrahydrofolate ([6S]-5-MTHF), could be an option for supplementation and fortification but its bioavailability remains unclear. This study compared the bioavailability of [6S]-5-MTHF ... -
Should vitamin B12 status be considered in assessing risk of neural tube defects?
(2018)There is a strong biological premise for including vitamin B12 with folic acid in strategies to prevent neural tube defects (NTDs), due to the closely interlinked metabolism of these two vitamins. For example, reduction ... -
SIGN-R1 contributes to protection against lethal pneumococcal infection in mice
(Rockefeller University Press, 2004)Rapid clearance of pathogens is essential for successful control of pyogenic bacterial infection. Previous experiments have shown that antibody to specific intracellular adhesion molecule-grabbing nonintegrin (SIGN)-R1 ... -
Silver nanoparticles as a medical device in healthcare settings: a five-step approach for candidate screening of coating agents
(2018)Silver nanoparticle-based antimicrobials can promote a long lasting bactericidal effect without detrimental toxic side effects. However, there is not a clear and complete protocol to define and relate the properties of ... -
Simultaneous disruption of Interleukin (IL)-4 and IL-13 defines individual roles in T Helper cell Type 2-mediated responses
(The Rockefeller University Press, 1999)Using a single vector targeting strategy, we have generated mice with a combined deficiency of interleukin (IL)-4 and IL-13 to clarify their roles in T helper type 2 (Th2) cell responses. Using immunological challenges ... -
Single Agent Antihypertensive Therapy and Orthostatic Blood Pressure Behaviour in Older Adults Using Beat-to-Beat Measurements: The Irish Longitudinal Study on Ageing.
(2016)Background Impaired blood pressure (BP) stabilisation after standing, defined using beat-to-beat mea- surements, has been shown to predict important health outcomes. We aimed to define the relationship between individual ...