Browsing Clinical Medicine by Title
Now showing items 601-620 of 947
-
Nanomedicines for the treatment of coagulation disorders
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Clinical Medicine, 2016)Nanomaterials are becoming increasingly utilised in all areas of science, technology and healthcare. More specifically in terms of nanomedicine, the physical and chemical properties of the materials allow for application ... -
Nanotechnology in pulmonary medicine
(2020)Nanotechnology in medicine-nanomedicine-is extensively employed to diagnose, treat, and prevent pulmonary diseases. Over the last few years, this brave new world has made remarkable progress, offering opportunities to ... -
Nanotoxicity in cancer research: technical protocols and tips considerations for the use of 3D tumour spheroids
(InTech, 2018)The poor clinical translation of oncological nanomedicine products is one of the greatest challenges faced by research today. The use of reductionist in vitro models of human cancer and non-predictive animal models is ... -
Needs of informal caregivers across the caregiving course in amyotrophic lateral sclerosis: a qualitative analysis
(2018)Objectives: Amyotrophic lateral sclerosis (ALS), also known as motor neuron disease (MND), is a debilitating terminal condition. Informal caregivers are key figures in ALS care provision. The physical, psychological and ... -
Neonatal adiposity increases the risk of atopic dermatitis during the first year of life.
(2016)BACKGROUND: Early nutrition and adiposity have been linked to atopic dermatitis (AD) development. OBJECTIVE: We sought to describe risk factors for AD in the first year of life in infants participating in the Cork ... -
The nerve of facial expression, impact of its anatomical variations on iatrogenic surgical injury and a novel MRI diffusion weighted imaging technique to image its intra-parotid course
(Trinity College Dublin. School of Medicine. Discipline of Clinical Medicine, 2018)This doctorate in clinical medicine set out to assess how variations in facial nerve anatomy to the intra-parotid venous system could impact on surgical access to the parotid gland or the mandible, and explored methods to ... -
Network Analysis in Amyotrophic Lateral Sclerosis during Voluntary Motor Task: Neurophysiological Biomarkers of Disrupted Cortical Connections
(Trinity College Dublin. School of Medicine. Discipline of Clinical Medicine, 2024)Amyotrophic lateral sclerosis (ALS) is a fatal progressive neurodegenerative disease that causes degeneration of both upper and lower motor neurons primarily affecting the motor system, but individual people with ALS show ... -
Network Analysis in Motor Neuron Diseases: A Cortico-Muscular Coherence Study
(Trinity College Dublin. School of Medicine. Discipline of Clinical Medicine, 2022)Neurodegenerative conditions are associated with widespread changes in the motor networks. There is preliminary evidence from (f)MRI studies that the structural changes extend beyond the primary motor areas in cortical ... -
Networked T Cell Death following Macrophage Infection by Mycobacterium tuberculosis.
(2012)Background: Depletion of T cells following infection by Mycobacterium tuberculosis (Mtb) impairs disease resolution, and interferes with clinical test performance that relies on cell-mediated immunity. A number of mechanisms ... -
NEURODEVELOPMENTAL OUTCOME FOR TWINS OF THE ESPRiT STUDY: THE NOTES STUDY
(Trinity College Dublin. School of Medicine. Discipline of Clinical Medicine, 2021)THE NOTES STUDY: ABSTRACT Objective: The objective of the NOTES Study was to study the effect of birthweight growth discordance (≥ 20%) on neurodevelopmental outcome and physical growth of monochorionic and dichorionic ... -
Neuroimaging correlates of disability in Motor Neuron Disease
(Trinity College Dublin. School of Medicine. Discipline of Clinical Medicine, 2024)Motor neuron diseases (MND) clinically present with a wide variety of motor and extra-motor symptoms. However, the pathological correlates of such symptom manifestation and their progression is poorly understood. In the ... -
Neuroimaging features of Amyotrophic Lateral Sclerosis
(Trinity College Dublin. School of Medicine. Discipline of Clinical Medicine, 2024)Novelty: Because the vast majority of ALS imaging studies focus on evaluating motor pathology, the focus and novelty of this work is the nuanced characterisation of extra-motor involvement in a genetically stratified cohort ... -
The Neuroimaging Features of Frontotemporal Dementia: Characterising Phenotype-Associated Pathological Changes In Vivo
(Trinity College Dublin. School of Medicine. Discipline of Clinical Medicine, 2023)Frontotemporal dementia (FTD) is a rare type of dementia. It can affect language, behaviour and memory depending on what part of the brain is involved. It can be difficult to diagnose, especially in the early stages of ... -
Neurophysiological markers of network dysfunction in neurodegenerative diseases
(Elsevier, 2019)There is strong clinical, imaging and pathological evidence that neurodegeneration is associated with altered brain connectivity. While functional imaging (fMRI) can detect resting and activated states of metabolic activity, ... -
Neuropsychological and Neuropsychiatric Endophenotypes in Amyotrophic Lateral Sclerosis
(Trinity College Dublin. School of Medicine. Discipline of Clinical Medicine, 2022)Amyotrophic Lateral Sclerosis (ALS) is a fatal neurodegenerative disease, characterized by progressive muscle weakness and death, usually within 3-5 years from symptom onset. ALS is now recognized to be a multi-system ... -
Neutralisation of the interleukin-33/ST2 pathway ameliorates experimental colitis through enhancement of mucosal healing in mice.
(2013)Inflammatory bowel diseases (IBD) have been intrinsically linked to a deregulated cytokine network, but novel therapeutic principles are urgently needed. Here we identify the interleukin (IL)-33 and its receptor ST2 as key ... -
New biochips for a three-dimensional study of transendothelial leukocyte migration
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Clinical Medicine, 2011)An important step in the inflammatory response is the recruitment of leukocytes into tissues through the endothelial cells which line blood vessels. Transendothelial migration (TEM) is the result of a multistep cascade in ... -
New fluorescent bile acids: Synthesis, chemical characterization, and disastereoselective uptake by Caco-2 cells of 3-deoxy 3-NBD-amino deoxycholic and ursodeoxycholic acid
(2012)Deoxycholic acid (DCA), a secondary bile acid (BA), and ursodeoxycholic acid (UDCA), a tertiary BA, cause opposing effects in vivo and in cell suspensions. Fluorescent analogues of DCA and UDCA could help investigate ... -
New highly toxic bile acids derived from deoxycholic acid, chenodeoxycholic acid and lithocholic acid.
(2014)We have prepared a new panel of 23 BA derivatives of DCA, chenodeoxycholic acid (CDCA) and lithocholic acid (LCA) in order to study the effect of dual substitution with 3-azido and 24- amidation, features individually ...
