Browsing Clinical Medicine by Title
Now showing items 534-553 of 948
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Macrophage immunometabolism in the host response to Mycobacterium tuberculosis infection
(Trinity College Dublin. School of Medicine. Discipline of Clinical Medicine, 2017)Tuberculosis (TB) is the leading infectious disease killer in the world, alongside HIV. Our understanding of the complex host immune response to Mycobacterium tuberculosis (Mtb) remains incomplete, but varied clinical ... -
Macrophages are critical drivers of synovial inflammation in Rheumatoid Arthritis
(Trinity College Dublin. School of Medicine. Discipline of Clinical Medicine, 2020)Macrophages are an exquisitely plastic pool of innate cells critically involved in directing the immune response in RA. Upon entry into the synovium, peripheral blood monocytes differentiate into the dichotomous M1 ... -
Making healthcare accessible for single adults with complex needs experiencing long-term homelessness: A realist evaluation protocol
(2021)Background: Over the last several years, homelessness has increased in Ireland and across Europe. Rates have recently declined since the coronavirus disease 2019 (COVID-19) pandemic, but it is unclear whether emergency ... -
Management of maternal HIV-1 infection in pregnancy : the experience of the GUIDE clinic
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Clinical Medicine, 2009)As of the end of 2007 there were an estimated 33.2 (30.6-36.1) million people worldwide living with HIV-1 or AIDS. Almost seven thousand new infections occurred ever day in 2007. Children under 15 years of age accounted ... -
Mapping Variation in Cellular and Transcriptional Response to 1,25-Dihydroxyvitamin D3 in Peripheral Blood Mononuclear Cells.
(2016)The active hormonal form of vitamin D, 1,25-dihydroxyvitamin D (1,25D) is an important modulator of the immune system, inhibiting cellular proliferation and regulating transcription of immune response genes. In order to ... -
Markers for work disability in anti-neutrophil cytoplasmic antibody-associated vasculitis.
(2014)Objectives. ANCA-associated vasculitis (AAV) commonly affects those of working age. Since survival rates have been transformed by immunotherapeutics, the measurement of other outcomes has become increasingly relevant. Work ... -
MASCC/ISOO expert opinion on the management of oral problems in patients with advanced cancer
(2022)Purpose: The Palliative Care Study Group in conjunction with the Oral Care Study Group of the Multinational Association for Supportive Care in Cancer (MASCC) formed a sub-group to develop evidence-based guidance on the ... -
Maternal choline concentrations during pregnancy and choline-related genetic variants as risk factors for neural tube defects
(2014)BACKGROUND: Low maternal choline intake and blood concentration may be risk factors for having a child with a neural tube defect (NTD); however, the data are inconsistent. This is an important question to resolve because ... -
Maternal folate, vitamin B12 and homocysteine levels in pregnancies affected by congenital malformations other than neural tube defects.
(2011)Background— Periconceptional use of folic acid prevents most neural tube defects (NTDs). Whether folic acid and/or multivitamins can prevent other congenital anomalies is not clear. This study tested whether maternal ... -
Maternal homocysteine before conception and throughout pregnancy predicts fetal homocysteine and birth weight.
(American Association for Clinical Chemistry, 2004)BACKGROUND: Increased homocysteine has been associated with pregnancy complications. METHODS: We investigated prospectively the effect of maternal homocysteine on normal pregnancy outcome. The study included 93 women and ... -
Measuring network disruption in neurodegenerative diseases: New approaches using signal analysis.
(2019)Advanced neuroimaging has increased understanding of the pathogenesis and spread of disease, and offered new therapeutic targets. MRI and positron emission tomography have shown that neurodegenerative diseases including ... -
Measuring particle concentration of multimodal synthetic reference materials and extracellular vesicles with orthogonal techniques: Who is up to the challenge?
(2021)The measurement of physicochemical properties of polydisperse complex biological samples, for example, extracellular vesicles, is critical to assess their quality, for example, resulting from their production and isolation ... -
Measuring particle size distribution and mass concentration of nanoplastics and microplastics: addressing some analytical challenges in the sub-micron size range
(2021)Hypothesis: The implementation of the proposal from the European Chemical Agency (ECHA) to restrict the use of nanoplastics (NP) and microplastics (MP) in consumer products will require reliable methods to perform size and ... -
Measuring reliable change in cognition using the Edinburgh Cognitive and Behavioural ALS Screen (ECAS)
(2018)Background: Cognitive impairment affects approximately 50% of people with amyotrophic lateral sclerosis (ALS). Research has indicated that impairment may worsen with disease progression. The Edinburgh Cognitive and Behavioural ... -
Mechanisms of human innate immune cell death and consequent adaptive immune responses during Mycobacterium tuberculosis infection
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Clinical Medicine, 2012)Mycobacterium tuberculosis (Mtb), the causative agent of tuberculosis, is a highly successful pathogen, infecting an estimated one-third of the global population. Mtb infection leads to the deaths of approximately 1.3 ... -
Mechanisms of immune evasion utilised by the Hepatitis C virus
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Clinical Medicine, 2009)Hepatitis C virus (HCV) is a small, enveloped RNA virus which is distributed worldwide and according to the WHO the number of infected individuals is estimated to be approximately 170 million. HCV creates a heavy burden ... -
Mental Capacity for Medical Treatment Decisions in Medical and Surgical Hospital Inpatients in Ireland
(Trinity College Dublin. School of Medicine. Discipline of Clinical Medicine, 2019)Mental capacity both merits and requires substantial consideration and attention in present-day clinical practice, research and legislation. This is the first research study in the Republic of Ireland to evaluate the ... -
Mental Disorders in Older Adults Admitted to General Hospitals: Review of Patient, Service Provision and Environmental Factors
(Trinity College Dublin. School of Medicine. Discipline of Clinical Medicine, 2022)The prevalence of mental illnesses in older general hospital inpatients has been studied widely however data from the Irish population is lacking. Psychiatry of Old Age Liaison (`POA Liaison¿) services provide assessment ...
