Browsing Clinical Medicine by Title
Now showing items 1-20 of 947
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2020 international consensus on ANCA testing beyond systemic vasculitis
(2020)This document follows up on a 2017 revised international consensus on anti-neutrophil cytoplasm antibodies (ANCA) testing in granulomatosis with polyangiitis and microscopic polyangiitis and focuses on the clinical and ... -
23. Lessons of ALS imaging: Pitfalls and future directions - A critical review.
(2014)Stereotypical shortcomings can be identified in ALS neuroimaging studies. • A systematic discussion of ALS study limitations is particularly timely. • Individual patient data meta-analyses and multicentre ... -
2nd ESMO Consensus Conference on Lung Cancer: early-stage non-small-cell lung cancer consensus on diagnosis, treatment and follow-up.
(2014)To complement the existing treatment guidelines for all tumour types, ESMO organises consensus conferences to focus on specific issues in each type of tumour. The 2nd ESMO Consensus Conference on Lung Cancer was held on ... -
A novel inflammatory mediator in sinus disease
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Clinical Medicine, 2006)Rhinosinusitis is one of the three most common disorders presenting to primary care physicians, generating high socioeconomic costs (Moss and Parsons 1986; Poole 1999). Understanding the pathomechanisms of inflammation, ... -
A novel protein NFKBIL-1 regulates the activity of key transcription factors
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Clinical Medicine, 2008)Inflammation is a physiological process initiated in response to an injury or infection. Proper execution of the inflammatory response requires activation of several pro- inflammatory transcription factors. Nuclear Factor ... -
A promising hypoxia-inducible suicide gene therapy strategy for prostate cancer
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Clinical Medicine, 2008)Gene therapy targeted to hypoxic tumour cells may allow selective killing of malignant cells. The induction of gene expression under hypoxic conditions is governed by the activation of hypoxia-inducible factor 1 and its ... -
A study of food consumption patterns of children and adults in Ireland : implications for the development of food-based dietary guidelines
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Clinical Medicine, 2006)Food-based dietary guidelines (FBDG) are guidelines derived from nutrient targets which are translated into food-based guidelines so they can be adopted by the general population. In order for FBDG to be successful, they ... -
A study of postprandial lipoprotein metabolism and glycaemic control in a population with type 2 diabetes mellitus
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Clinical Medicine, 2010)Postprandial hypertriglyceridaemia predicts cardiovascular disease and is a characteristic of both obesity and poorly controlled diabetes. To address the relative impact of improved glycaemic control and weight loss on ... -
A surgical delivery system for targeted cancer gene therapy : the potential therapeutic role of genetically modified microvascular free flaps in the management of primary tumours
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Clinical Medicine, 2009)Gene therapy has generated interest for the treatment of soft tissue malignancies. It offers the theoretical promise of delivering cytotoxic, immunomodulatory, or anti- angiogenic genes to produce proteins targeting tumour ... -
Activated Factor X signaling via protease-activated receptor 2 suppresses pro-inflammatory cytokine prodution from LPS-stimulated myeloid cells.
(2014)Vitamin K-dependent proteases generated in response to vascular injury and infection enable fibrin clot formation, but also trigger distinct immuno-regulatory signaling pathways on myeloid cells. Factor Xa, a protease ... -
Activating CARD14 Mutations Are Associated with Generalized Pustular Psoriasis but Rarely Account for Familial Recurrence in Psoriasis Vulgaris.
(2015)Caspase recruitment family member 14 (CARD14, also known as CARMA2), is a scaffold protein that mediates NF-κB signal transduction in skin keratinocytes. Gain-of-function CARD14 mutations have been documented in familial ... -
Activation and cleavage of SASH1 by caspase-3 mediates an apoptotic response
(2016)Apoptosis is a highly regulated cellular process that functions to remove undesired cells from multicellular organisms. This pathway is often disrupted in cancer, providing tumours with a mechanism to avoid cell death and ... -
Active case finding of tuberculosis in Europe: a Tuberculosis Network European Trials Group (TBNET) survey
(2008)Tuberculosis control depends on successful case finding and treatment of individuals infected with Mycobacterium tuberculosis. Passive case finding is widely practised: the present study aims to ascertain the consensus and ... -
Acute Stroke Care in Ireland - The Role of a National Audit in Improving Care
(Trinity College Dublin. School of Medicine. Discipline of Clinical Medicine, 2020)Background: The 2008 Irish national audit of stroke service (INASC) showed large deficits in service provision and access. A national stroke programme emerged to develop services and address these deficits. The country ... -
Adaption of the Functional Lumen Imaging Probe for non-radiological evaluation of the upper oesophageal sphincter
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Clinical Medicine, 2014)The aim of this research was to adapt the Functional Lumen Imaging Probe (FLIP), a novel non-radiological measurement tool, to measure upper oesophageal sphincter (DOS) distensibility and opening patterns during swallowing. ... -
Adaptive and Innate TH1 and TH17 Responses in Elderly Hospitalised Patients with Infection and Sepsis
(Trinity College Dublin. School of Medicine. Discipline of Clinical Medicine, 2021)Introduction: Sepsis carries a significant burden to health care. Almost a third of ICU patients have sepsis on admission or develop it during their admission. Sepsis carries a high mortality and affects all age groups ... -
Adaptive immune response in human Staphylococcus aureus bloodstream infection
(Trinity College Dublin. School of Medicine. Discipline of Clinical Medicine, 2019)Staphylococcus aureus bloodstream infection is a common and life-threatening condition. Treatment outcomes are poor, suboptimal clinical management is common, antimicrobial resistance continues to emerge, and there are few ... -
Addition of a Viral Immunomodulatory Domain to Etanercept Generates a Bifunctional Chemokine and TNF Inhibitor
(2020)The inhibition of tumor necrosis factor (TNF) through the use of either antibodies or soluble receptors is a highly effective strategy for the clinical control of chronic inflammatory conditions such as rheumatoid arthritis. ... -
Adenylate cyclase toxin of Bordetella pertussis inhibits TLR-induced IRF-1 and IRF-8 activation and IL-12 production and enhances IL-10 through MAPK activation in dendritic cells.
(2008)Adenylate cyclase toxin (CyaA) of Bordetella pertussis binds to CD11b/CD18 on macrophages and dendritic cells (DC) and confers virulence to the bacteria by subverting innate immune responses of the host. We have previously ...