Browsing Clinical Medicine by Title
Now showing items 930-949 of 949
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Variation in clinical outcomes and immune consequences following two viral infections
Ageing is associated with increasing rates of ill-health. However, the burden of ill-health is not evenly distributed across ageing populations. The term biological age captures the consequences of ageing more effectively ... -
Vascular biomarkers of cognitive performance in a community-based elderly population: the Dublin Healthy Ageing study.
(2008)BACKGROUND: population studies suggest that cardiovascular risk factors may be associated with cognitive impairment. Epidemiological studies evaluating individual markers of vascular disease as risk factors for cognitive ... -
Vascular correlates of cognitive performance in a community based elderly population
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Clinical Medicine, 2010)Population studies suggest that cardiovascular risk factors may be associated with cognitive impairment. Epidemiological studies evaluating individual markers of vascular disease as a risk factor for cognitive dysfunction ... -
Vascular disease is associated with the expression of genes for intestinal cholesterol transport and metabolism
(2017)Context: Intestinal cholesterol metabolism is important in influencing postprandial lipoprotein concentrations, and might be important in the development of vascular disease. Objective: This study evaluated associations ... -
Vascular endothelial growth factor is an autocrine growth factor, signaling through neuropilin-1 in non-small cell lung cancer
(2015)BACKGROUND: The VEGF pathway has become an important therapeutic target in lung cancer, where VEGF has long been established as a potent pro-angiogenic growth factor expressed by many types of tumors. While Bevacizumab ... -
Virtual brain biopsies in amyotrophic lateral sclerosis: diagnostic classification based on in vivo pathological patterns
(2017)Background: Diagnostic uncertainty in ALS has serious management implications and delays recruitment into clinical trials. Emerging evidence of presymptomatic disease-burden provides the rationale to develop diagnostic ... -
Virulent Mycobacterium tuberculosis Strains Evade Apoptosis of Infected Alveolar Macrophages
(2000)Human alveolar macrophages (AMφ) undergo apoptosis following infection with Mycobacterium tuberculosis in vitro. Apoptosis of cells infected with intracellular pathogens may benefit the host by eliminating a supportive ... -
Vital signs in palliative care: a scoping review
(2023)Vital signs are routinely measured in secondary healthcare settings and can be used to detect clinical problems, guide treatment, and monitor response to treatment. Vital signs are less frequently measured in palliative ... -
Vitamin B12 in the elderly and its relationship to cognition, falls and balance, mood and mortality
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Clinical Medicine, 2011)Observational studies to date have provided conflicting evidence with respect to the clinical relevance of vitamin B12 status in elderly patients. The aims of this work were to establish the relationship of vitamin B12 ... -
Vitamin D deficiency: cognition, mortality and resource utilisation - prospective associations
(Trinity College Dublin. School of Medicine. Discipline of Clinical Medicine, 2019)Introduction: The association between Vitamin D and bone health has long been known. In recent times there has been increasing research into the effects of Vitamin D beyond this well-established link. Although there has ... -
Vitamin D in ageing: an investigation into the role of vitamin D in cognitive and physical functioning in coummunity-dwelling older adults
(Trinity College Dublin. School of Medicine. Discipline of Clinical Medicine, 2018)With our growing older population, there is an increasing need to identify potentially modifiable characteristics or interventions that are intended to enhance the functioning of older adults who could be described as ... -
Vitamin D in older adults and its relationship to cognition, blood pressure, mood and falls
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Clinical Medicine, 2014)An increasing body of evidence supports a role for vitamin D in cognition, blood pressure, mood and falls. Vitamin D deficiency is prevalent in older adults and might provide an alternative novel treatment strategy for ... -
Vitamin D in the elderly and its relationship to inflammation and cognitive health
(Trinity College Dublin. School of Medicine. Discipline of Clinical Medicine, 2020)Background: There is a major shift in ageing demographics as individuals are experiencing increased longevity. This shift may be beneficial for the individual who will live into more advanced year than their ancestors. ... -
Von Willebrand factor propeptide in severe coronavirus disease 2019 (COVID-19): evidence of acute and sustained endothelial cell activation
(2021)Endothelial cell (EC) activation plays a key role in the pathogenesis of pulmonarymicrovascular occlusion, which is a hallmark of severe coronavirus disease 2019(COVID-19). Consistent with EC activation, increased plasma ... -
Von Willebrand Factor, osteoprotegerin and protein C pathway in the pathogenesis of experimental cerebal malaria
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Clinical Medicine, 2015)Plasmodium falciparum malaria infection is associated with an early marked increase in plasma VWF levels, together with a pathological accumulation of hyperreactive ultra-large VWF (ULVWF) multimers. Given the established ... -
What does the ALSFRS-R really measure? A longitudinal and survival analysis of functional dimension subscores in amyotrophic lateral sclerosis
(2017)Introduction: ALSFRS-R is the most widely used functional rating system in ALS patients. However, heterogeneity in ALSFRS-R progression renders analysis challenging. We have explored the characteristics of total ALSFRS-R, ... -
Women's compliance with current folic acid recommendations and achievement of optimal vitamin status for preventing neural tube defects.
(2011)BACKGROUND The timing of folic acid supplement usage is critical to preventing pregnancies affected by neural tube defects (NTDs) because the neural tube closes by Day 28 post-conception. We investigated compliance of ... -
Xerostomia in patients with advanced cancer: a scoping review of clinical features and complications
(2023)Background: The aim of this project was to review the literature on dry mouth / xerostomia in patients with advanced cancer, with the objectives being to determine its prevalence, clinical features, and complications. Methods: ...