Browsing Clinical Medicine by Title
Now showing items 92-111 of 949
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The C-type lectin SIGNR1 binds Schistosoma mansoni antigens in vitro, but SIGNR1-deficient mice have normal responses during schistosome infection
(American Society for Microbiology, 2009)The de novo immune response to infectious organisms arises from the innate recognition of pathogen-associated molecular patterns (PAMPs) by the host's pattern recognition receptors (PRRs). As the generation of type 2 ... -
C3 glomerulopathy: consensus report.
(2013)C3 glomerulopathy is a recently introduced pathological entity whose original definition was glomerular pathology characterized by C3 accumulation with absent or scanty immunoglobulin deposition. In August 2012, an invited ... -
C5L2, a nonsignalling C5A receptor is uncoupled to G proteins
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Clinical Medicine, 2008)The complement anaphylatoxins are prominent mediators of host defence and inflammation. The small subunit of the fifth component of complement, C5a has complex effects in vivo including potential anti- and pro-inflammatory ... -
Can bacterial virulence factors predict antibiotic resistant Helicobacter pylori infection?
(2018)AIM: To evaluate the association between virulence factor status and antibiotic resistance in Helicobacter pylori (H. pylori)-infected patients in Ireland. METHODS: DNA was extracted from antral and corpus biopsies ... -
Can the systematic use of non-invasive biomarkers in patients with lower gastrointestional sysmtpoms help rationalise the demand for limited endoscopy resources?
(Trinity College Dublin. School of Medicine. Discipline of Clinical Medicine, 2020)Introduction: Gastrointestinal complaints are very common in the general population. Demand for endoscopy continues to outstrip capacity, despite significant annual increase in the number of endoscopies performed nationwide, ... -
Cancer Cachexia - Prevalence and Predictors in Treatment-naive Patients
(Trinity College Dublin. School of Medicine. Discipline of Clinical Medicine, 2020)Title: Cancer Cachexia Prevalence and Predictors in Treatment-naïve Patients Candidate Name: Dr Niamh O Donoghue Background Cancer cachexia is a common wasting syndrome, yet it remains poorly understood and under-recognised. ... -
Cancer risks for BRCA1 and BRCA2 mutation carriers: Results from prospective analysis of EMBRACE
(2013)Background Reliable estimates of cancer risk are critical for guiding management of BRCA1 and BRCA2 mutation carriers. The aims of this study were to derive penetrance estimates for breast cancer, ovarian cancer, ... -
Cancer Symptom Clusters: An Exploratory Analysis of Eight Statistical Techniques
(2014)PURPOSE: Low serum 25-hydroxyvitamin D [25(OH)D] levels have been linked to both cancer incidence and poor prognosis. The frequency of 25(OH)D tests and clinical factors associated with low levels in cancer patients are ... -
Cancer-related insomnia
(2014)Insomnia increases cancer symptom burden and impairs quality of life. The lack of standard definitions and treatment guidelines makes management difficult. Insomnia is common in most cancers but appears particularly so in ... -
Candidate role for TLR3 L412F in disease progression in Idiopathic Pulmonary Fibrosis (IPF) during bacterial and viral infection
(Trinity College Dublin. School of Medicine. Discipline of Clinical Medicine, 2019)In this thesis, we investigated the mechanisms by which TLR3 Leu412Phe (L412F) promotes disease progression in idiopathic pulmonary fibrosis (IPF) patients. IPF is a fatal interstitial lung disease of unknown aetiology and ... -
Capsule endoscopy with artificial intelligence-assisted technology: Real-world usage of a validated AI model for capsule image review
(2023)Background and study aims Capsule endoscopy is a time-consuming procedure with a significance error rate. Artificial intelligence (AI) can potentially reduce reading time significantly by reducing the number of images ... -
Cardiovascular risk in non-diabetes mellitus insulin resistant states
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Clinical Medicine, 2012)This thesis explores the various cardiovascular risks that occur in insulin resistant states apart from type 2 diabetes mellitus (T2DM). Various cardiovascular risk markers and metabolic derangements related to cardiovascular ... -
Caregiving in ALS - A mixed methods approach to the study of Burden
(2016)Background Caregiver burden affects the physical, psychological and emotional well-being of the caregiver. The purpose of this analysis was to describe an informal caregiver cohort (n = 81), their subjective assessment ... -
Carrier status for the common R501X and 2282del4 filaggrin mutations is not associated with hearing phenotypes in 5,377 children from the ALSPAC cohort
(2009)Background: Filaggrin is a major protein in the epidermis. Several mutations in the filaggrin gene (FLG) have been associated with a number of conditions. Filaggrin is expressed in the tympanic membrane and could alter its ... -
Caspase-1-dependent inflammasomes mediate photoreceptor cell death in photo-oxidative damage-induced retinal degeneration.
(2020)Activation of the inflammasome is involved in the progression of retinal degenerative diseases, in particular, in the pathogenesis of Age-Related Macular Degeneration (AMD), with NLRP3 activation the focus of many ... -
A caspase-independent pathway mediates macrophage cell death in response to Mycobacterium tuberculosis infection.
(2007)Macrophages can undergo apoptosis after infection with Mycobacterium tuberculosis. This macrophage response deprives the bacillus of its niche cell and supports the host response through better antigen presentation. The ... -
CCNF mutations in amyotrophic lateral sclerosis and frontotemporal dementia
(2016)Amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD) are overlapping, fatal neuro-degenerative disorders in which the molecular and pathogenic basis remains poorly understood. Ubiquitinated ... -
CD3ε Expression Defines Functionally Distinct Subsets of Vδ1 T Cells in Patients With Human Immunodeficiency Virus Infection.
(2018)Human γδ T cells expressing the Vδ1 T cell receptor (TCR) recognize self and microbial antigens and stress-inducible molecules in a major histocompatibility complex-unrestricted manner and are an important source of innate ...