Browsing Clinical Medicine by Title
Now showing items 621-640 of 949
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New fluorescent bile acids: Synthesis, chemical characterization, and disastereoselective uptake by Caco-2 cells of 3-deoxy 3-NBD-amino deoxycholic and ursodeoxycholic acid
(2012)Deoxycholic acid (DCA), a secondary bile acid (BA), and ursodeoxycholic acid (UDCA), a tertiary BA, cause opposing effects in vivo and in cell suspensions. Fluorescent analogues of DCA and UDCA could help investigate ... -
New highly toxic bile acids derived from deoxycholic acid, chenodeoxycholic acid and lithocholic acid.
(2014)We have prepared a new panel of 23 BA derivatives of DCA, chenodeoxycholic acid (CDCA) and lithocholic acid (LCA) in order to study the effect of dual substitution with 3-azido and 24- amidation, features individually ... -
NF-κB regulation: The nuclear response
(2009)Nuclear factor ?B (NF-?B) is an inducible transcription factor that tightly regulates the expression of a large cohort of genes. As a key component of the cellular machinery NF-?B is involved in a wide range of biological ... -
Nivolumab plus ipilimumab in non-small-cell lung cancer
(2019)Nivolumab and ipilimumab, two therapeutic immune checkpoint inhibitor antibodies that block PD-1and CTLA-4, respectively, have indications in cancer as single agents and in combination. In this Review, we examine the ... -
NK cells in childhood obesity are activated, metabolically stressed, and functionally deficient
(2017)Childhood obesity is a major global concern, with over 50 million children now classified as obese. Obesity has been linked to the development of numerous chronic inflammatory diseases, including type 2 diabetes and multiple ... -
No effect of an oleoylethanolamide-related phospholipid on satiety and energy intake: a randomised controlled trial of phosphatidylethanolamine
(BioMed Central, 2008)Phosphatidylethanolamine (PE) is a phospholipid which is biosynthesized into long chain N-acylethanolamines (NAEs) including oleoylethanolamide (OEA), a known inhibitor of food intake. The aim of this study was to investigate ... -
Nomenclature and Definition of Atrophic Lesions in Small Bowel Capsule Endoscopy: An International Delphi Consensus Statement of the International CApsule Endoscopy REsearch (I-CARE) Group.
(2022)Background: Villous atrophy is an indication for small bowel capsule endoscopy (SBCE). However, SBCE findings are not described uniformly and atrophic features are sometimes not recognized; (2) Methods: The Delphi technique ... -
Non-invasive molecular tests for H. pylori
(Cogoro, 2016) -
Notch-RBP-J signaling regulates the transcription factor IRF8 to promote inflammatory macrophage polarization.
(2012)Emerging concepts suggest that the functional phenotype of macrophages is regulated by transcription factors that define alternative activation states. We found that RBP-J, the main nuclear transducer of signaling via Notch ... -
Novel Mechanisms of Resistance to Enzalutamide in Prostate Cancer
(Trinity College Dublin. School of Medicine. Discipline of Clinical Medicine, 2023)Prostate cancer (PCa) is the second most common invasive cancer in men worldwide. In Ireland, PCa is the third leading cause of male cancer related mortality. AR directed therapies have remained the primary therapeutic ... -
Novel mediators regulating innate and adaptive type 17 immune responses
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Clinical Medicine, 2014)The discovery of a third subset of T helper cells and more recently innate T cell subsets which preferentially express IL-17A has led to intensive investigation into the roles these cells play in both host defence and ... -
Novel molecular targets in advanced prostate cancer
(Trinity College Dublin. School of Medicine. Discipline of Clinical Medicine, 2019)Prostate Cancer (PCa) is the most commonly diagnosed cancer in men and a leading cause of morbidity and mortality among men in the United States and Western Europe. The aim of initial treatment in advanced PCa is to reduce ... -
Novel Screening Strategies for HIV, Hepatitis B and C Infection
(Trinity College Dublin. School of Medicine. Discipline of Clinical Medicine, 2018)Abstract Title: Novel Screening Strategies for HIV, Hepatitis B and C Infection. Author: Dr Sarah O?Connell Introduction: Despite prevention measures in place, rates of HIV infection have failed to decline in Ireland in ... -
NRF2 in liver injury and repair: its relevance to liver transplantation
(Trinity College Dublin. School of Medicine. Discipline of Clinical Medicine, 2022)Liver transplantation is the only effective curative treatment for end-stage liver disease and modern-day practice has led to excellent survival outcomes. Ensuring access to suitable allografts remains crucial as patients ... -
Nucleophosmin: From structure and function to disease development
(2016)Nucleophosmin (NPM1) is a critical cellular protein that has been implicated in a number of pathways including mRNA transport, chromatin remodeling, apoptosis and genome stability. NPM1 function is a critical requirement ... -
Nuocytes represent a new innate effector leukocyte that mediates type-2 immunity.
(2010)Innate immunity provides the first line of defence against invading pathogens and provides important cues for the development of adaptive immunity. Type-2 immunity-responsible for protective immune responses to helminth ... -
Nursing home staff mental health during the COVID-19 pandemic in the Republic of Ireland
(Trinity College Dublin. School of Medicine. Discipline of Clinical Medicine, 2023)This thesis comprises three main studies. The aim of this project was to characterise nursing home staff mental health during the COVID-19 pandemic in the Republic of Ireland. Study 1: Cross-sectional survey of nursing ... -
Nutritional and metabolic aspects of n-3 polyunsaturated fatty acids in health and disease
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Clinical Medicine, 2000)The health benefits of fish oils, rich in the n-3 polyunsaturated fatty acids (PUFA) eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) are multi-faceted, spanning a number of human systems, including the cardiovascular, ...