Browsing Clinical Medicine by Title
Now showing items 581-600 of 949
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Molecular mechanisms of resistance to therapeutic MEK inhibition in BRAF [V600E] cancer
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Clinical Medicine, 2013)Aberrant activation of the mitogen activated protein kinase (MAPK) pathway is common in solid tumours. This hierarchical pathway consists of a three-tiered kinase casade of BRAF, MAPK kinase (MEK1/2) and the extracellular ... -
Molecular Medicine Ireland Guidelines for Standardized Biobanking
(Mary Ann Liebert, Inc, 2010) -
Motor and extra-motor involvement in amyotrophic lateral sclerosis
(Trinity College Dublin. School of Medicine. Discipline of Clinical Medicine, 2019)Amyotrophic Lateral Sclerosis (ALS) is primarily associated with pathology in the motor cortex and corticospinal tract. Based on clinical observations, it is increasingly recognised that extra-motor symptoms add to the ... -
Movement-related cortical potentials in paraplegic patients: abnormal patterns and considerations for BCI-rehabilitation.
(2014)Non-invasive EEG-based Brain-Computer Interfaces (BCI) can be promising for the motor neuro-rehabilitation of paraplegic patients. However, this shall require detailed knowledge of the abnormalities in the EEG signatures ... -
Mucosal Associated Invariant T Cells and Insulin Resistance in Hidradenitis Suppurativa
(Trinity College Dublin. School of Medicine. Discipline of Clinical Medicine, 2023)Hidradenitis suppurativa (HS) is a chronic, inflammatory skin disease characterised by recurrent painful nodules, abscesses and draining sinus tracts. There is a paucity of effective treatments and it severely impairs ... -
Multi-ancestry genome-wide association study of 21,000 cases and 95,000 controls identifies new risk loci for atopic dermatitis.
(2015)Genetic association studies have identified 21 loci associated with atopic dermatitis risk predominantly in populations of European ancestry. To identify further susceptibility loci for this common, complex skin disease, ... -
The multifunctional role of filaggrin in allergic skin disease.
(2013)Filaggrin is a major structural protein in the stratum corneum of the epidermis. Mutations in the filaggrin gene are the most significant known genetic risk factor for the development of atopic dermatitis. Mutations in the ... -
Multilayered Cultures of NSCLC cells grown at the Air-Liquid Interface allow the efficacy testing of inhaled anti-cancer drugs
(2018)Evidence supports the advantages of inhalation over other drug-administration routes in the treatment of lung diseases, including cancer. Although data obtained from animal models and conventional in vitro cultures are ... -
Multimodal Analysis for Brain Network Fingerprints in Parkinson's Disease Patients
(Trinity College Dublin. School of Medicine. Discipline of Clinical Medicine, 2023)Parkinson's disease is a neurodegenerative disorder that causes structural and functional abnormalities in the central nervous system. The disease leads to the development of cardinal motor symptoms, including bradykinesia, ... -
Multinational Association of Supportive Care in Cancer (MASCC) expert opinion / guidance on the use of clinically-assisted hydration in patients with advanced cancer
(2024)Purpose: The provision of clinically assisted hydration (CAH) in patients with advanced cancer is controversial, and there is a paucity of specific guidance and so a diversity in clinical practice. Consequently, the ... -
Multinational Association of Supportive Care in Cancer (MASCC) expert opinion/guidance on the use of clinically assisted nutrition in patients with advanced cancer
(2022)Purpose: The pro vision of clinically assisted nutrition (CAN) in patients with advanced cancer is controversial, and there is a paucity of specific guidance, and so a diversity in clinical practice. Consequently, the ... -
Multiparametric evaluation of magnetic nanoparticles for theranostic applications in breast and pancreatic cancer
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Clinical Medicine, 2016)Magnetic iron oxide nanoparticles (MNP) are superparamagnetic below 30 nm in size, have high surface to volume ratio in the nanometre size range, display no remnant magnetism in the absence of a magnetic field yet have ... -
Multiparametric MRI study of ALS stratified for the C9orf72 genotype
(2013)Objective: To describe the patterns of cortical and subcortical changes in amyotrophic lateral sclerosis (ALS) stratified for the C9orf72 genotype. Methods: A prospective, single-center, single-protocol, gray and ... -
Multiple common variants for celiac disease influencing immune gene expression
(2010)We performed a second-generation genome-wide association study of 4,533 individuals with celiac disease (cases) and 10,750 control subjects. We genotyped 113 selected SNPs with P(GWAS) < 10(-4) and 18 SNPs from 14 known ... -
Multiple norovirus infections in a birth cohort in a Peruvian peri-urban community.
(2014)Human noroviruses are among the most common enteropathogens globally, and are a leading cause of infant diarrhea in developing countries. However, data measuring the impact of norovirus at the community level are ... -
The multistep hypothesis of ALS revisited
(Wolters Kluwer Health, 2018)Objective: Amyotrophic lateral sclerosis (ALS) incidence rates are consistent with the hypothesis that ALS is a multistep process. We tested the hypothesis that carrying a large effect mutation might account for≥1 steps ... -
Mutations in the Glycosyltransferase Domain of GLT8D1 Are Associated with Familial Amyotrophic Lateral Sclerosis
(2019)Amyotrophic lateral sclerosis (ALS) is a severe neurodegenerative disorder without effective neuroprotective therapy. Known genetic variants impair pathways, including RNA processing, axonal transport, and protein homeostasis. ... -
Mutations in the SASPase gene (ASPRV1) are not associated with atopic eczema or clinically dry skin
(Europe PMC Funders, 2012) -
Mycobacterium tuberculosis infection induces non-apoptotic cell death of human dendritic cells.
(2011)BACKGROUND: Dendritic cells (DCs) connect innate and adaptive immunity, and are necessary for an efficient CD4+ and CD8+ T cell response after infection with Mycobacterium tuberculosis (Mtb). We previously described the ...