Browsing Clinical Medicine by Title
Now showing items 526-545 of 949
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Loss-of-function variants in the filaggrin gene are a significant risk factor for peanut allergy.
(2011)Background IgE-mediated peanut allergy is a complex trait with strong heritability, but its genetic basis is currently unknown. Loss-of-function mutations within the filaggrin gene are associated with atopic dermatitis ... -
Low 25-hydroxyvitamin D levels in peopel with a solid tumor cancer diagnosis: the tip of the iceberg?
(2014)PURPOSE: Low serum 25-hydroxyvitamin D [25(OH)D] levels have been linked to both cancer incidence and poor prognosis. The frequency of 25(OH)D tests and clinical factors associated with low levels in cancer patients are ... -
Low colonocyte folate is associated with uracil misincorporation and global DNA hypomethylation in human colorectum.
(2013)Low folate status is a risk factor for colon carcinogenesis; mechanisms proposed to account for this relationship include uracil misincorporation into DNA and global DNA hypomethylation. We investigated whether such ... -
Low Density Granulocytes in ANCA Vasculitis Are Heterogenous and Hypo-Responsive to Anti-Myeloperoxidase Antibodies
(2019)Low Density Granulocytes (LDGs), which appear in the peripheral blood mononuclear cell layer of density-separated blood, are seen in cancer, sepsis, autoimmunity, and pregnancy. Their significance in ANCA vasculitis (AAV) ... -
Low Density Granulocytes in ANCA Vasculitis Are Heterogenous and Hypo-Responsive to Anti-Myeloperoxidase Antibodies.
(2019)Low Density Granulocytes (LDGs), which appear in the peripheral blood mononuclear cell layer of density-separated blood, are seen in cancer, sepsis, autoimmunity, and pregnancy. Their significance in ANCA vasculitis (AAV) ... -
Low vitamin B-12 status and risk of cognitive decline in older adults.
(2007)BACKGROUND: Elevated total homocysteine (tHcy) concentrations have been associated with cognitive impairment, but it is unclear whether low vitamin B-12 or folate status is responsible for cognitive decline. OBJECTIVE: We ... -
Lower gastrointestinal symptoms and symptoms-based triaging systems are poor predictors of clinical significant disease on colonoscopy.
(2020)Introduction: Lower gastrointestinal symptoms (LGS) are a common cause of referral to the gastroenterology service. International guidelines are available to prioritise referrals. Some studies have reported that symptoms ... -
Lymph node status and coagulation biomarkers as predictors of venous thromboembolism in gynaecological cancer patients post surgery
(Trinity College Dublin. School of Medicine. Discipline of Clinical Medicine, 2024)Venous thromboembolism (VTE) is a major complication of cancer ranging from 4- 20% depending on tumour type and stage. VTE risk increases post-surgical treatment especially in the first 90 days post-surgery. The precise ... -
Lymphomagenesis, hydronephrosis, and autoantibodies result from dysregulation of IL-9 and are differentially dependent on Th2 cytokines
(2009-09-17)Interleukin-9 is an immunoregulatory cytokine implicated in the development of asthma and allergy. To investigate the role of IL-9 in vivo, we have generated transgenic mice in which IL-9 is expressed from its own promoter. ... -
Macrophage immunometabolism in the host response to Mycobacterium tuberculosis infection
(Trinity College Dublin. School of Medicine. Discipline of Clinical Medicine, 2017)Tuberculosis (TB) is the leading infectious disease killer in the world, alongside HIV. Our understanding of the complex host immune response to Mycobacterium tuberculosis (Mtb) remains incomplete, but varied clinical ... -
Macrophages are critical drivers of synovial inflammation in Rheumatoid Arthritis
(Trinity College Dublin. School of Medicine. Discipline of Clinical Medicine, 2020)Macrophages are an exquisitely plastic pool of innate cells critically involved in directing the immune response in RA. Upon entry into the synovium, peripheral blood monocytes differentiate into the dichotomous M1 ... -
Making healthcare accessible for single adults with complex needs experiencing long-term homelessness: A realist evaluation protocol
(2021)Background: Over the last several years, homelessness has increased in Ireland and across Europe. Rates have recently declined since the coronavirus disease 2019 (COVID-19) pandemic, but it is unclear whether emergency ... -
Management of maternal HIV-1 infection in pregnancy : the experience of the GUIDE clinic
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Clinical Medicine, 2009)As of the end of 2007 there were an estimated 33.2 (30.6-36.1) million people worldwide living with HIV-1 or AIDS. Almost seven thousand new infections occurred ever day in 2007. Children under 15 years of age accounted ... -
Mapping Variation in Cellular and Transcriptional Response to 1,25-Dihydroxyvitamin D3 in Peripheral Blood Mononuclear Cells.
(2016)The active hormonal form of vitamin D, 1,25-dihydroxyvitamin D (1,25D) is an important modulator of the immune system, inhibiting cellular proliferation and regulating transcription of immune response genes. In order to ... -
Markers for work disability in anti-neutrophil cytoplasmic antibody-associated vasculitis.
(2014)Objectives. ANCA-associated vasculitis (AAV) commonly affects those of working age. Since survival rates have been transformed by immunotherapeutics, the measurement of other outcomes has become increasingly relevant. Work ... -
MASCC/ISOO expert opinion on the management of oral problems in patients with advanced cancer
(2022)Purpose: The Palliative Care Study Group in conjunction with the Oral Care Study Group of the Multinational Association for Supportive Care in Cancer (MASCC) formed a sub-group to develop evidence-based guidance on the ... -
Maternal choline concentrations during pregnancy and choline-related genetic variants as risk factors for neural tube defects
(2014)BACKGROUND: Low maternal choline intake and blood concentration may be risk factors for having a child with a neural tube defect (NTD); however, the data are inconsistent. This is an important question to resolve because ... -
Maternal folate, vitamin B12 and homocysteine levels in pregnancies affected by congenital malformations other than neural tube defects.
(2011)Background— Periconceptional use of folic acid prevents most neural tube defects (NTDs). Whether folic acid and/or multivitamins can prevent other congenital anomalies is not clear. This study tested whether maternal ...