Browsing Clinical Medicine by Title
Now showing items 486-505 of 949
-
An Investigation into Helicobacter pylori Treatment Outcomes and Host Responses
(Trinity College Dublin. School of Medicine. Discipline of Clinical Medicine, 2023)Helicobacter pylori (H. pylori) is a helical, gram-negative, micro-aerophilic bacterium that infects approximately 50% of the world?s population. Although many of those infected will be asymptomatic, H. pylori increases ... -
Investigation into the Pathophysiology and the Objective Neurophysiological Measurement of Cancer-Related Fatigue in a Pre-Treatment Cancer Cohort
(Trinity College Dublin. School of Medicine. Discipline of Clinical Medicine, 2020)Cancer-related fatigue (CRF) is one of the most common, debilitating, highly prevalent and unrelenting symptom experienced by patients through all stages of the cancer trajectory and often into survivorship (Berger et al., ... -
Investigation of ABO blood group expresser phenotype
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Clinical Medicine, 2011)The aims of this project were to study the variability of the ABO blood group expression on human platelets and to explore the underlying molecular mechanisms. 541 Irish blood donors were studied. The recently described ... -
Investigation of cortical and sub-cortical processing of pressure pain transduction in healthy controls and chronic lumbar radicular pain pre and post oxycodone treatment-An event related fMRI study.
(Trinity College Dublin. School of Medicine. Discipline of Clinical Medicine, 2018)Background: - Few scientific developments have been more striking than the ability to measure the activity of the functioning human brain. Experimental acute pain stimulus in healthy controls can predict with more than 90% ... -
An investigation of epigenetic effects in Atherosclerosis
(Trinity College Dublin. School of Medicine. Discipline of Clinical Medicine, 2017)Epigenetic mechanisms may explain some of the missing heritability associated with CVD and how external factors such as diet, environment and lifestyle contribute to disease development and progression. This thesis aimed ... -
Investigation of gene amplification and expression in prostate cancer
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Clinical Medicine, 2007)The purpose of this thesis was to identify significant genetic amplifications and protein expression of a gene or genes that have not been recognised as overamplified to date in prostate cancer. Methods used: -- 1) ... -
Investigation of interactions of nanoparticles with components of the human vascular microenvironment : platelets, plasma and endothelial cells
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Clinical Medicine, 2012)Nanotechnology is defined as ‘the understanding and control of matter at dimensions less than 100 nanometers’, and exploits the novel physical, chemical and biological properties of materials. Nanomedicine, application of ... -
Investigation of lymph node transplantation as therapy for breast cancer related lymphedema
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Clinical Medicine, 2009)Humans have hundreds of lymph nodes, collections of which are found in the underarms, groin, neck, chest, and abdomen. They have long been considered 'neutral' elements in terms of lymph transport. An assumption has always ... -
Investigation of retinal thickness using optical coherence tomography: a prospective phenotype study of patients with inherited ataxia
(Trinity College Dublin. School of Medicine. Discipline of Clinical Medicine, 2022)Inherited cerebellar ataxias (CA) are clinically and genetically heterogeneous disorders. A diverse range of ophthalmic abnormalities have been reported in different subtypes of CA and, although visual symptoms are not ... -
Investigation of the monogenic causes of chronic kidney disease
(Trinity College Dublin. School of Medicine. Discipline of Clinical Medicine, 2020)Chronic Kidney Disease (CKD) is a common chronic condition that affects 15 percent of adults in the Irish healthcare system. End stage kidney disease (ESKD) represents the final stage of CKD which culminates in the need ... -
Investigation of the role of immunomodulators oftoll-like receptor 3 (TLR3) function and associated genetic variants in the pathogenesis and progression of idiopathic pulmonary fibrosis (IPF)
(Trinity College Dublin. School of Medicine. Discipline of Clinical Medicine, 2024)IPF is a fatal interstitial lung disease of unknown aetiology, with a lack of valid biomarkers and satisfactory therapeutic solutions available. Studies have shown an association between inflammation, viral and bacterial ... -
Investigation of the role of RACKI in T lymphocyte migration
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Clinical Medicine, 2012)Induction of the innmune response and production of pro-inflammatory cytokines results in the upregulation of ICAM-1 expressed on endothelial cells. Binding of ICAM-1 to the β2 integrin receptor LFA-1 on T cells induces T ... -
Investigations into the role of mast cell mediated effects on the intestinal epithelial barrier in vitro : implications for the pathogenesis of irritable bowel syndrome
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Clinical Medicine, 2013)Irritable bowel syndrome (IBS) is a highly prevalent functional bowel disorder characterised by abdominal pain or discomfort and associated with altered bowel habit, abdominal bloating and disturbed defecation. The aetiology ... -
The Iron Chelator Desferrioxamine Increases the Efficacy of Bedaquiline in Primary Human Macrophages Infected with BCG
(2021)For over 50 years, patients with drug-sensitive and drug-resistant tuberculosis have undergone long, arduous, and complex treatment processes with several antimicrobials. With the prevalence of drug-resistant strains on ... -
Is low iron status a risk factor for neural tube defects?
(2014)Background: Folic acid supplements can protect against neural tube defects (NTDs). Low folate and low vitamin B12 status may be maternal risk factors for having an NTD affected pregnancy. However, not all NTDs are preventable ... -
Joint Nutrition Society and Irish Nutrition and Dietetic Institute Symposium on Nutrition and autoimmune disease Nutrition in Crohn s disease
(Cambridge University Press, 2009)The exact aetiology of Crohn's disease remains unknown. The consensus is that the disease results from a complex interaction between genes, immunity and environmental factors. Diet is attractive, in theory, as an environmental ... -
July 2017 ENCALS statement on edaravone
(2017)Neurologists of the ENCALS centers throughout Europe have discussed the potential of edaravone as anew therapy for amyotrophic lateral sclerosis (ALS,Motor Neuron Disease, MND) at the ENCALS meeting, 18–20 May 2017, in ... -
Kaposi sarcoma in an patient with atopic dermatitis treated with ciclosporin.
(2013)There are four clinical subtypes of Kaposi sarcoma (KS): classic, endemic, epidemic and iatrogenic. The geographical prevalence of the endemic variant matches areas of human herpes virus type 8 (HHV8) seroprevalence. The ... -
Ketamine for depression: Clinical use and media accounts
(Trinity College Dublin. School of Medicine. Discipline of Clinical Medicine, 2021)This thesis comprises two research studies, one of which is a clinical trial. Study 1: Pilot randomised controlled trial: Ketamine as an adjunctive therapy for major depression, the Karma-Dep Trial (NCT03256162). The ... -
Key research questions for implementation of artificial intelligence in capsule endoscopy.
(2022)Background: Artificial intelligence (AI) is rapidly infiltrating multiple areas in medicine, with gastrointestinal endoscopy paving the way in both research and clinical applications. Multiple challenges associated with ...