Browsing Clinical Medicine by Title
Now showing items 479-498 of 949
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Investigating Molluscum Contagiosum Virus Protein MC008 and its Effect on Inflammatory Signalling
(Trinity College Dublin. School of Medicine. Discipline of Clinical Medicine, 2023)Molluscum contagiosum virus (MCV) is a human-adapted poxvirus that causes a common, persistent, yet mild infection characterized by distinct, contagious, papular skin lesions. These lesions are notable for having little ... -
Investigating novel targets of DNA methylation for the early detection of prostate cancer
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Clinical Medicine, 2007)Prostate cancer is an escalating international health problem. It is the most common non- cutaneous malignancy and the second leading cause of cancer related deaths in men in the Western world. Like many other cancers, ... -
Investigating protein and gene biomarker expression, specifically chemokine (C-X-C motif) ligand 16 (CXCL16), associated with cardiovascular diseases using a combination of in vitro and in vivo techniques
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Clinical Medicine, 2014)A patient based study was designed to analyze serum concentrations of 10 known inflammatory markers, GM-CSF, IFN-γ, IL-10, IL-12p70,IL-1β, IL-2, IL-6, IL-8, TNF-a and CXCL16 in asymptomatic and symptomatic pre-operative ... -
Investigating the Potential and Pitfalls of EV-Encapsulated MicroRNAs as Circulating Biomarkers of Breast Cancer
(2020)Extracellular vesicles (EVs) shuttle microRNA (miRNA) throughout the circulation and are believed to represent a fingerprint of the releasing cell. We isolated and characterized serum EVs of breast tumour-bearing animals, ... -
Investigating the role of constitutively active truncated androgen receptor splice variants in prostate cancer
(Trinity College (Dublin, Ireland). School of Medicine, 2012)The androgen receptor (AR) is fundamental for the growth and survival of normal and malignant prostate cells. Therefore, androgen deprivation therapy remains the first‐line treatment for disseminated disease, however, ... -
Investigating the role of DNA hypermethylation as a key controller of aberrant cell death in prostate cancer
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Clinical Medicine, 2010)Prostate cancer remains a global public health problem. Worldwide, it is the most common noncutaneous cancer in men and is a leading cause of cancer- related deaths among men in North America and Westem\Northem Europe. ... -
Investigating the role of IL-36 cytokines in mediating angiogenesis and vascular permeability
(Trinity College Dublin. School of Medicine. Discipline of Clinical Medicine, 2021)Neovascular blinding conditions including age related macular degeneration and diabetic retinopathy are the most common causes of blindness in the elderly and working age populations respectively. Currently the best-in-class ... -
An Investigation into Helicobacter pylori Treatment Outcomes and Host Responses
(Trinity College Dublin. School of Medicine. Discipline of Clinical Medicine, 2023)Helicobacter pylori (H. pylori) is a helical, gram-negative, micro-aerophilic bacterium that infects approximately 50% of the world?s population. Although many of those infected will be asymptomatic, H. pylori increases ... -
Investigation into the Pathophysiology and the Objective Neurophysiological Measurement of Cancer-Related Fatigue in a Pre-Treatment Cancer Cohort
(Trinity College Dublin. School of Medicine. Discipline of Clinical Medicine, 2020)Cancer-related fatigue (CRF) is one of the most common, debilitating, highly prevalent and unrelenting symptom experienced by patients through all stages of the cancer trajectory and often into survivorship (Berger et al., ... -
Investigation of ABO blood group expresser phenotype
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Clinical Medicine, 2011)The aims of this project were to study the variability of the ABO blood group expression on human platelets and to explore the underlying molecular mechanisms. 541 Irish blood donors were studied. The recently described ... -
Investigation of cortical and sub-cortical processing of pressure pain transduction in healthy controls and chronic lumbar radicular pain pre and post oxycodone treatment-An event related fMRI study.
(Trinity College Dublin. School of Medicine. Discipline of Clinical Medicine, 2018)Background: - Few scientific developments have been more striking than the ability to measure the activity of the functioning human brain. Experimental acute pain stimulus in healthy controls can predict with more than 90% ... -
An investigation of epigenetic effects in Atherosclerosis
(Trinity College Dublin. School of Medicine. Discipline of Clinical Medicine, 2017)Epigenetic mechanisms may explain some of the missing heritability associated with CVD and how external factors such as diet, environment and lifestyle contribute to disease development and progression. This thesis aimed ... -
Investigation of gene amplification and expression in prostate cancer
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Clinical Medicine, 2007)The purpose of this thesis was to identify significant genetic amplifications and protein expression of a gene or genes that have not been recognised as overamplified to date in prostate cancer. Methods used: -- 1) ... -
Investigation of interactions of nanoparticles with components of the human vascular microenvironment : platelets, plasma and endothelial cells
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Clinical Medicine, 2012)Nanotechnology is defined as ‘the understanding and control of matter at dimensions less than 100 nanometers’, and exploits the novel physical, chemical and biological properties of materials. Nanomedicine, application of ... -
Investigation of lymph node transplantation as therapy for breast cancer related lymphedema
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Clinical Medicine, 2009)Humans have hundreds of lymph nodes, collections of which are found in the underarms, groin, neck, chest, and abdomen. They have long been considered 'neutral' elements in terms of lymph transport. An assumption has always ... -
Investigation of retinal thickness using optical coherence tomography: a prospective phenotype study of patients with inherited ataxia
(Trinity College Dublin. School of Medicine. Discipline of Clinical Medicine, 2022)Inherited cerebellar ataxias (CA) are clinically and genetically heterogeneous disorders. A diverse range of ophthalmic abnormalities have been reported in different subtypes of CA and, although visual symptoms are not ... -
Investigation of the monogenic causes of chronic kidney disease
(Trinity College Dublin. School of Medicine. Discipline of Clinical Medicine, 2020)Chronic Kidney Disease (CKD) is a common chronic condition that affects 15 percent of adults in the Irish healthcare system. End stage kidney disease (ESKD) represents the final stage of CKD which culminates in the need ... -
Investigation of the role of immunomodulators oftoll-like receptor 3 (TLR3) function and associated genetic variants in the pathogenesis and progression of idiopathic pulmonary fibrosis (IPF)
(Trinity College Dublin. School of Medicine. Discipline of Clinical Medicine, 2024)IPF is a fatal interstitial lung disease of unknown aetiology, with a lack of valid biomarkers and satisfactory therapeutic solutions available. Studies have shown an association between inflammation, viral and bacterial ... -
Investigation of the role of RACKI in T lymphocyte migration
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Clinical Medicine, 2012)Induction of the innmune response and production of pro-inflammatory cytokines results in the upregulation of ICAM-1 expressed on endothelial cells. Binding of ICAM-1 to the β2 integrin receptor LFA-1 on T cells induces T ... -
Investigations into the role of mast cell mediated effects on the intestinal epithelial barrier in vitro : implications for the pathogenesis of irritable bowel syndrome
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Clinical Medicine, 2013)Irritable bowel syndrome (IBS) is a highly prevalent functional bowel disorder characterised by abdominal pain or discomfort and associated with altered bowel habit, abdominal bloating and disturbed defecation. The aetiology ...