Browsing Microbiology by Title
Now showing items 1-20 of 320
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The A domain of fibronectin-binding protein B of Staphylococcus aureus contains a novel fibronectin binding site.
(2011)The fibronectin‐binding proteins FnBPA and FnBPB are multifunctional adhesins than can also bind to fibrinogen and elastin. In this study, the N2N3 subdomains of region A of FnBPB were shown to bind fibrinogen with a similar ... -
Accelerated Evolution of Lager Yeast Strains for Improved Flavour Profiles
(Trinity College Dublin. School of Genetics & Microbiology. Discipline of Microbiology, 2022)S. pastorianus is an interspecific hybrid resulting from natural hybridization between S. cerevisiae and S. eubayanus. These two species belong to the Saccharomyces genus, a genus that encompasses different species related ... -
Activation of plasminogen by staphylokinase reduces the severity of Staphylococcus aureus systemic infection
(2010)Background. Staphylokinase (SAK) is produced by the majority of Staphylococcus aureus strains. It is an extracellular protein that activates the conversion of human plasminogen (plg) to plasmin. The role played by SAK in ... -
Adhesion and invasion by Escherichia coli K1
(Trinity College (Dublin, Ireland). Department of Microbiology, 2006)Escherichia coli is one of the principal causes of septicaemia and meningitis in neonates. Sepsis occurs in approximately one in every thousand live births, with up to 10% progressing to develop meningitis. A disproportionate ... -
Adhesion, invasion and evasion: the many functions of the surface proteins of Staphylococcus aureus
(2014)Staphylococcus aureus is an important opportunistic pathogen and persistently colonizes about 20% of the human population. Its surface is 'decorated' with proteins that are covalently anchored to the cell wall peptidoglycan. ... -
Analysis of tetracycline resistance encoded by transposon Tn10: deletion mapping of tetracycline-sensitive point mutations and identification of two structural genes
(1983)Deletions in the tet genes derived from Tn10 were formed from different tet::Tn5 insertion mutations by removing DNA sequences located between a HindIII site in Tn5 and a HindIII site adjacent to the tet genes. ... -
Analysis of the chloramphenicol resistance determinant of plasmid R26
(Trinity College (Dublin, Ireland). Department of Microbiology, 1985)The Inc P-1 plasmid, R2B carries an inducible chloramphenicol resistance determinant, cml. This specifies low level chloramphenicol resistance (30 μg/ml] in Escherichia coli. The mechanism does not involve drug detoxification ... -
Analysis of the effects of Beta-Amyloid and age on cell signalling in rat hippocampus : effect of treatment with polyunsaturated fatty acids
(Trinity College (Dublin, Ireland). Department of Microbiology, 2005)Long-term potentiation (LTP) is considered to be a possible neurophysiological model for learning and memory and consistent with this, is the observation that LTP is sensitive to stress, injury and insult. This thesis ... -
Analysis of the function of the N1 subdomain of MSCRAMMs of Staphylococcus aureus
(Trinity College (Dublin, Ireland). Department of Microbiology, 2014)The Microbial Surface Component Recognising Adhesive Matrix Molecules (MSCRAMMs) family of cell wall-associated proteins have recently been reclassified based on structure-function analysis. Under this new regime the MSCRAMM ... -
Analysis of the genomic organisation and gene expression of brewery strains of yeast
(Trinity College (Dublin, Ireland). Department of Microbiology, 2008)The genomes of lager yeast arose from the fusion of two yeast strains most closely resembling Saccharomyces cerevisiae and Saccharomyces bayanus. The resultant strains have subsequently undergone genome duplications ... -
Analysis of the role of human papillomaviruses and the p53/Rb tumour suppressor genes in the development of cutaneous squamous cell carcinoma
(Trinity College (Dublin, Ireland). Department of Microbiology, 2000)Nonmelanoma skin cancers (NMSC) are the most frequent cancers in Caucasian populations. Renal transplant recipients (RTR) are at an increased risk of neoplasia, particularly skin cancer. Studies on anogenital cancer have ... -
Aneuploidy influences the gene expression profiles in Saccharomyces pastorianus group I and II strains during fermentation
(2022)The lager yeasts, Saccharomyces pastorianus, are hybrids of Saccharomyces cerevisiae and Saccharomyces eubayanus and are divided into two broad groups, Group I and II. The two groups evolved from at least one common ... -
Anti-disease therapy for malaria: 'resistance proof'?
(2013)Antimalarial drugs have in the past fallen prey to resistance and this problem is likely to continue in the future. One approach to developing drugs that might be less prone to resistance might be to target the disease ... -
Anti-malarial effects of macrolactones related to FK520 (ascomycin) are independent of the immunosuppressive properties of the compounds
(University of Chicago Press, 2005)The polyketide macrolactone FK506 inhibits the growth of Plasmodium falciparum in culture and the enzymatic (peptidyl-prolyl cis-trans isomerase [PPIase]) and chaperone activities of a recently identified P. falciparum ... -
Antimalarial drug discovery and design in the Era of resistance
(2013)These are interesting times for antimalarial drug research. On the one hand, recent reports from Southeast Asia paint a grim picture of reduced malarial parasite susceptibility to artemisinin combination therapies ... -
Antimalarial peptides: the long and the short of it
(2011)Antimicrobial peptides include a diverse array of both natural and synthetic molecules varying greatly in size, charge, hydrophobicity and secondary-structural features. Although better known as antibacterial agents, many ...