Browsing Microbiology by Title
Now showing items 215-234 of 320
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Overexpression, purification and assessment of cyclosporin binding of a family of cyclophilins and cyclophilin-like proteins of the human malarial parasite Plasmodium falciparum
(2011)Malaria represents a global health, economic and social burden of enormous magnitude. Chemotherapy is at the moment a largely effective weapon against the disease, but the appearance of drug-resistant parasites is reducing ... -
P53 CODON 72 POLYMORPHISM AND HUMAN PAPILLOMAVIRUS ASSOCIATED SKIN CANCER
(2001)BACKGROUND/AIMS-NON-MELANOMA SKIN CANCERS FREQUENTLY HARBOUR MULTIPLE HUMAN PAPILLOMAVIRUS (HPV) TYPES. A RECENT REPORT SUGGESTS THAT ALPOLYMORPHISM OF THE P53 TUMOUR SUPPRESSOR GENE THAT RESULTS IN THE SUBSTITUTION OF A ... -
Packing a punch: Understanding how flavours are produced in lager fermentations
(2021)Beer is one of the most popular beverages in the world and it has an irreplaceable place in culture. Although invented later than ale, lager beers dominate the current market. Many factors relating to the appearance (colour, ... -
Pathogenomic analysis of the common bovine Staphylococcus aureus clone (ET3): emergence of a virulent subtype with potential risk to public health
(University of Chicago Press, 2008)A common clone (ET3) of Staphylococcus aureus is responsible for a large proportion of cases of bovine mastitis and occasionally causes zoonotic infections of humans. In the present study, we report the identification of ... -
Percy Kirwan - Long Jumper, Triple Jumper and Olympic Judge
(The Athletics Association of Ireland, 2013) -
Pervasive post-transcriptional control of genes involved in amino acid metabolism by the Hfq-dependent GcvB small RNA.
(2011)GcvB is one of the most highly conserved Hfq-associated small RNAs in Gram-negative bacteria and was previously reported to repress several ABC transporters for amino acids. To determine the full extent of GcvB-mediated ... -
PEST sequences in the malaria parasite Plasmodium falciparum: a genomic study
(BioMed Central, 2003)Anopheles gambiae is the main vector of Plasmodium falciparum in Africa. The mosquito midgut constitutes a barrier that the parasite must cross if it is to develop and be transmitted. Despite the central role of the mosquito ... -
Plasmodium berghei ANKA: selection of resistance to piperaquine and lumefantrine in a mouse model.
(Elsevier, 2009)We have selected piperaquine (PQ) and lumefantrine (LM) resistant Plasmodium berghei ANKA parasite lines in mice by drug pressure. Effective doses that reduce parasitaemia by 90% (ED90) of PQ and LM against the parent line ... -
Platelet activation by Staphylococcus aureus
(Trinity College (Dublin, Ireland). Department of Microbiology, 2006)Staphylococcus aureus is the leading cause of infective endocarditis (IE). Platelet activation promoted by S. aureus resulting in aggregation and thrombus formation is thought to be an important step in the pathogenesis ... -
The PolyA tail length of yeast histone mRNAs varies during the cell cycle and is influenced by Sen1p and Rrp6p
(2012)Yeast histone mRNAs are polyadenylated, yet factors such as Rrp6p and Trf4p, required for the 3?-end processing of non-polyadenylated RNAs, contribute to the cell cycle regulation of these transcripts. Here, we investigated ... -
Population genomics of the pathogenic yeast Candida tropicalis identifies hybrid isolates in environmental samples
(2021)Candida tropicalis is a human pathogen that primarily infects the immunocompromised. Whereas the genome of one isolate, C. tropicalis MYA-3404, was originally sequenced in 2009, there have been no large-scale, multi-isolate ... -
Posttranscriptional regulation of the inducible nonenzymatic chloramphenicol resistance determinant of IncP plasmid R26
(1985)The inducible nonenzymatic chloramphenicol resistance (Cmr) determinant of the IncP plasmid R26 was cloned on a 1,900-base-pair restriction endonuclease HindIII fragment. Transposon Tn5 mutagenesis revealed that at least ... -
A potential new pathway for Staphylococcus aureus dissemination: silent survival of S.aureus phagocytosed by human monocyte-derived macrophages.
(2008)Although considered to be an extracellular pathogen, Staphylococcus aureus is able to invade a variety of mammalian, non-professional phagocytes and can also survive engulfment by professional phagocytes such as neutrophils ... -
Preventing protein-dependent biofilm formation in Staphylococcus aureus by targeting the serine aspartate repeat protein C and fibronectin binding proteins
(Trinity College (Dublin, Ireland). Department of Microbiology, 2017)Staphylococcus aureus is a leading cause of biofilm infections on indwelling medical devices. S. aureus biofilm infections are intrinsically difficult to treat. They are recalcitrant to conventional antibiotics and resistant ... -
Protein A Is Released into the Staphylococcus aureus Culture Supernatant with an Unprocessed Sorting Signal.
(2015)The immunoglobulin binding protein A (SpA) of Staphylococcus aureus is synthesized as a precursor with a C-terminal sorting signal. The sortase A enzyme mediates covalent attachment to peptidoglycan so that SpA is displayed ... -
Protein-based biofilm matrices in Staphylococci.
(2014)Staphylococcus aureus and Staphylococcus epidermidis are the most important etiological agents of biofilm associated-infections on indwelling medical devices. Biofilm infections may also develop independently of indwelling ...