Browsing Microbiology by Title
Now showing items 173-192 of 320
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Key role for clumping factor B in Staphylococcus aureus nasal colonization of humans.
(2008)Staphylococcus aureus permanently colonizes the vestibulum nasi of one-fifth of the human population, which is a risk factor for autoinfection. The precise mechanisms whereby S. aureus colonizes the nose are still unknown. ... -
Lactobacillus spp. for Gastrointestinal Health: Current and Future Perspectives
(2022)In recent decades, probiotic bacteria have become increasingly popular as a result of mounting scientific evidence to indicate their beneficial role in modulating human health. Although there is strong evidence associating ... -
Loss of microRNA-21 influences the gut microbiota causing reduced susceptibility in a murine model of colitis.
(2018)Background and aims: microRNAs regulate gene expression and influence the pathogenesis of human diseases. The present study investigated the role of microRNA-21 [miR-21] in the pathogenesis of intestinal inflammation, ... -
Mechanical strength and inhibition of the Staphylococcus aureus collagen-binding protein Cna
(2016)The bacterial pathogen Staphylococcus aureus expresses a variety of cell surface adhesion proteins that bind to host extracellular matrix proteins. Among these, the collagen (Cn)-binding protein Cna plays important roles ... -
Metabolic engineering of yeasts by heterologous enzyme production for degradation of cellulose and hemicellulose from biomass: a perspective
(2014)This review focuses on current approaches to metabolic engineering of ethanologenic yeast species for the production of bioethanol from complex lignocellulose biomass sources. The experimental strategies for the degradation ... -
Microevolution in Helicobacter pylori
(Trinity College (Dublin, Ireland). Department of Microbiology, 2002)Helicobacter pylori chronically colonises the human gastric mucosa. It is a major cause of chronic active gastritis and peptic ulcer disease and is associated with the development of gastric neoplasia. The population ... -
MicroRNA-21 Limits Uptake of Listeria monocytogenes by Macrophages to Reduce the Intracellular Niche and Control Infection.
(2017)MiRNAs are important post-transcriptional regulators of gene expression. MiRNA expression is a crucial part of host responses to bacterial infection, however there is limited knowledge of their impact on the outcome of ... -
Modelling staphylococcal pneumonia in a human 3D lung tissue model system delineates toxin-mediated pathology
(2015)Staphylococcus aureus necrotizing pneumonia is recognized as a toxin-mediated disease, yet the tissue-destructive events remain elusive, partly as a result of lack of mechanistic studies in human lung tissue. In this study, ... -
Molecular analysis of surface proteins of staphylococci
(Trinity College (Dublin, Ireland). Department of Microbiology, 2004)S. lugdunensis is an important human pathogen that causes 44% of coagulase negative staphylococcal native valve endocarditis as well as infections such as osteomyelitis and soft tissue abscesses. S. lugdunensis expresses ... -
Molecular analysis of the interaction between protein A of Staphylococcus aureus and von Willebrand factor
(Trinity College (Dublin, Ireland). Department of Microbiology, 2007)Staphylococcus aureus continues to be a major cause of infection in normal as well as immunocompromised hosts, and the increasing prevalence of highly virulent community acquired methicillin-resistant strains is a public ... -
Molecular characterisation of agn43 and its encoded protein, antigen 43, the major phase-variable outer membrane protein of Escherichia coli
(Trinity College (Dublin, Ireland). Department of Microbiology, 2001)A number of year ago workers in this laboratory identified antigen 43 (Ag43) during a systematic immunochemical analysis of the envelopes of Escherichia coli ML308-225 O13:O68:H . This Escherichia-specific outer membrane ... -
Molecular characterisation of Region A of FnBPA from Staphylococcus aureus
(Trinity College (Dublin, Ireland). Department of Microbiology, 2007)The surface-expressed fibronectin-binding proteins, FnBPA and FnBPB, of Staphylococcus aureus promote attachment to immobilised fibrinogen and elastin via the N-Terminal A region. The N2N3 subdomains of region A were found ... -
Molecular characterisation of the Salmonella-specific protein PagN
(Trinity College (Dublin, Ireland). Department of Microbiology, 2007)Salmonella infect a broad spectrum of animals resulting in host responses ranging from severe disease to asymptomatic carriage. Infection of a host gives rise to symptoms such as fever or self-limiting gastroenteritis. ... -
Molecular characterization of the interaction of staphylococcal microbial surface components recognizing adhesive matrix molecules (MSCRAMMS) ClfA and Fbl with fibrinogen
(2010)The ligand binding domain of the fibrinogen binding protein from Staphylococcus lugdunensis (Fbl) shares 60% sequence identity with clumping factor A (ClfA) of Staphylococcus aureus. Recombinant Fbl corresponding to the ...
