Emerging role for members of the Bcl-2 family in mitochondrial morphogenesis.
Item Type:Journal Article
Citation:Autret A, Martin SJ, Emerging role for members of the Bcl-2 family in mitochondrial morphogenesis., Molecular cell, 36, 3, 2009, 355-63
Autret-2009-Emerging Role for Me.pdf (Published (publisher's copy)) 655.2Kb
Summary Bcl-2 family proteins regulate apoptosis by controlling the release of mitochondrial cytochrome c via the Bax/Bak channel. However, recent studies have also implicated several members of this family in the regulation of mitochondrial fission/fusion dynamics. It has been debated whether the role of Bcl-2 proteins in mitochondrial morphogenesis is functionally distinct from their role in apoptosis, with some arguing that Bax/Bak-induced mitochondrial fission promotes apoptosis-associated cytochrome c release, while others suggest that these functions are separable. Here we review this emerging area and argue for a role for the Bcl-2 family as novel regulators of mitochondrial morphogenesis.
Author: MARTIN, SEAMUS
Type of material:Journal Article
Series/Report no:Molecular cell
Availability:Full text available