Emerging role for members of the Bcl-2 family in mitochondrial morphogenesis.
Citation:
Autret A, Martin SJ, Emerging role for members of the Bcl-2 family in mitochondrial morphogenesis., Molecular cell, 36, 3, 2009, 355-63Download Item:
Abstract:
Summary Bcl-2 family proteins regulate apoptosis by controlling the release of mitochondrial cytochrome c via the Bax/Bak channel. However, recent studies have also implicated several members of this family in the regulation of mitochondrial fission/fusion dynamics. It has been debated whether the role of Bcl-2 proteins in mitochondrial morphogenesis is functionally distinct from their role in apoptosis, with some arguing that Bax/Bak-induced mitochondrial fission promotes apoptosis-associated cytochrome c release, while others suggest that these functions are separable. Here we review this emerging area and argue for a role for the Bcl-2 family as novel regulators of mitochondrial morphogenesis.
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http://people.tcd.ie/martinsjDescription:
PUBLISHED
Author: MARTIN, SEAMUS
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Journal ArticleCollections
Series/Report no:
Molecular cell36
3
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Full text availableKeywords:
mitochondrial morphogenesisDOI:
http://dx.doi.org/10.1016/j.molcel.2009.10.011ISSN:
1097-2765Metadata
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