No evidence that runs of homozygosity are associated with schizophrenia in an Irish genome-wide association dataset
Item Type:Journal Article
Citation:Heron, E.A., Cormican, P., Donohoe, G., O'Neill, F.A., Kendler, K.S., Riley, B.P., Gill, M., Corvin, A.P., Morris, D.W., No evidence that runs of homozygosity are associated with schizophrenia in an Irish genome-wide association dataset, Schizophrenia Research, 154, 1-3, 2014, 79 82
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Runs of homozygosity (ROH), regions of the genome containing many consecutive homozygous SNPs, may represent two copies of a haplotype inherited from a common ancestor. A rare variant on this haplotype could thus be present in a homozygous and potentially recessive state. To detect rare risk variants for schizophrenia, we performed an ROH analysis in a homogeneous Irish genome wide association study (GWAS) dataset consisting of 1606 cases and 1794 controls. There was no genome-wide excess of ROH in cases compared to controls (p = 0.7986). No consensus ROH at individual loci showed association with schizophrenia after genome-wide correction.
Type of material:Journal Article
Series/Report no:Schizophrenia Research
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