Runs of homozygosity implicate autozygosity as a schizophrenia risk factor.
File Type:
PDFItem Type:
Journal ArticleDate:
2012Citation:
Keller MC, Simonson MA, Ripke S, Neale BM, Gejman PV, Howrigan DP, Lee SH, Lencz T, Levinson DF, Sullivan PF, Runs of homozygosity implicate autozygosity as a schizophrenia risk factor., PLoS genetics, 8, 4, 2012, e1002656Download Item:
pgen.1002656.pdf (Published (author's copy) - Peer Reviewed) 521.8Kb
Abstract:
Autozygosity occurs when two chromosomal segments that are identical from a common ancestor are inherited from each
parent. This occurs at high rates in the offspring of mates who are closely related (inbreeding), but also occurs at lower
levels among the offspring of distantly related mates. Here, we use runs of homozygosity in genome-wide SNP data to
estimate the proportion of the autosome that exists in autozygous tracts in 9,388 cases with schizophrenia and 12,456
controls. We estimate that the odds of schizophrenia increase by
,
17% for every 1% increase in genome-wide autozygosity.
This association is not due to one or a few regions, but results from many autozygous segments spread throughout the
genome, and is consistent with a role for multiple recessive or partially recessive alleles in the etiology of schizophrenia.
Such a bias towards recessivity suggests that alleles that increase the risk of schizophrenia have been selected against over
evolutionary time.
Author's Homepage:
http://people.tcd.ie/acorvinhttp://people.tcd.ie/morrisdw
http://people.tcd.ie/mgill
Description:
PUBLISHEDType of material:
Journal ArticleCollections:
Series/Report no:
PLoS genetics;8;
4;
Availability:
Full text availableKeywords:
etiology of schizophreniaLicences: