Browsing Histopathology & Morbid Anatomy by Title
Now showing items 47-66 of 105
-
Identification of novel biomarkers in recurrent / chemoresistant ovarian cancer
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Histopathology & Morbid Anatomy, 2009)The aim of this study was to identify novel biomarkers in recurrent/chemoresistant ovarian cancer, yet an incurable disease. Using cDNA microarrays, we identified distinct patterns of gene expression between primary and ... -
Identification, isolation and validation of ovarian cancer stem cells
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Histopathology & Morbid Anatomy, 2013)Ovarian cancer is often diagnosed at a late stage. Even so, it often responds (~73 %) to first-line therapies. However, the five year survival rate for late stage ovarian cancer is poor (~27 %). It is hypothesised that ... -
Identifying novel hypoxia-associated markers of chemoresistance in ovarian cancer
(2015)Background: Ovarian cancer is associated with poor long-term survival due to late diagnosis and development of chemoresistance. Tumour hypoxia is associated with many features of tumour aggressiveness including increased ... -
"If you can't treat HPV, why test for it?" Women's attitudes to the changing face of cervical cancer prevention: A focus group study
(2014)Open Access Research article “If you can’t treat HPV, why test for it?” Women’s attitudes to the changing face of cervical cancer prevention: a focus group study Judith McRae1*, Cara Martin2, John O’Leary3, Linda Sharp1 ... -
In vitro Development of Chemotherapy and Targeted Therapy Drug-Resistant Cancer Cell Lines: A Practical Guide with Case Studies.
(2014)The development of a drug-resistant cell line can take from 3 to 18 months. However, little is published on the methodology of this development process. This article will discuss key decisions to be made prior to starting ... -
An integrated analysis of the SOX2 microRNA response program in human pluripotent and nullipotent stem cell lines.
(2014)BACKGROUND: SOX2 is a core component of the transcriptional network responsible for maintaining embryonal carcinoma cells (ECCs) in a pluripotent, undifferentiated state of self-renewal. As such, SOX2 is an oncogenic ... -
Investigation of autoantibody profiling to reveal biomarkers of ovarian cancer
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Histopathology & Morbid Anatomy, 2013)Ovarian cancer is the most deadly gynaecological malignancy and 70% of all women with ovarian cancer die within 5 years of diagnosis. When diagnosed in early stages, ovarian cancer is curable in 90% of cases, however early ... -
Investigation of oral and oropharyngeal squamous cell carcinoma in young adults
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Histopathology & Morbid Anatomy, 2006)While oral and pharyngeal squamous cell carcinoma is classically a disease of older male smokers, this tumour type can occur in young patients with minimal or no exposure to the traditional risk factors. The prognosis ... -
MicroRNA profiling in prostate cancer and prostate derived holoclone cell model
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Histopathology & Morbid Anatomy, 2012)Prostate cancer is a heterogeneous disease and is the most commonly diagnosed malignant tumour and the second most common cause of cancer deaths in western males. Prostate cancer is the most commonly diagnosed cancer in ... -
MicroRNA-17 is downregulated in esophageal adenocarcinoma cancer stem-like cells and promotes a radioresistant phenotype
(2017)Resistance to neoadjuvant chemoradiation therapy (CRT) remains a critical barrier to the effective treatment of esophageal adenocarcinoma (EAC). Cancer stem-like cells (CSCs) are a distinct subpopulation of cells implicated ... -
miRNA profiles as a predictor of chemoresponsiveness in Wilms' tumor blastema.
(2013)The current SIOP treatment protocol for Wilms’ tumor involves pre-operative chemotherapy followed by nephrectomy. Not all patients benefit equally from such chemotherapy. The aim of this study was to generate a miRNA profile ... -
Molecular algorithms in ovarian serous neoplasia
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Histopathology & Morbid Anatomy, 2009)Epithelial ovarian cancer is one of the most common cancers in women and the leading cause of death from gynaecological malignancy in the western world. Approximately 205,000 cases of ovarian cancer are diagnosed worldwide ... -
Molecular algorithms in thyroid neoplasia
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Histopathology & Morbid Anatomy, 2005)Papillary thyroid carcinoma is the most comm on thyroid malignancy, with an incidence of <100 cases per year in Ireland and 16,000 cases per year in the U.S. Incidence is increasing with a global estimate of half a million ... -
Molecular analysis of Human Herpes Virus 8 and associated lesions
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Histopathology & Morbid Anatomy, 2003)This thesis looks at the bio-pathways of HHV8 through the transformation of endothelial cell lines. This was performed in two separate but mutually contributing experiments. First, endothelial cell lines were infected using ... -
Molecular characterisation of a new variant of inflammatory bowel disease in children with autism
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Histopathology & Morbid Anatomy, 2004)A new variant of inflammatory bowel disease, provisionally termed "autistic enterocolitis" has been described in a cohort of children with autistic spectrum disorders. The intestinal pathology includes ileo-colonic ... -
Molecular features of aggressive prostate carcinoma
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Histopathology & Morbid Anatomy, 2015)Prostate cancer is the most common form of malignancy in the male urinary tract and accounts for more than 20% of all newly diagnosed male cancer cases. The vast majority of prostate tumours are clinically insignificant, ... -
Molecular gene and regulatory profiles in thyroid cancer
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Histopathology & Morbid Anatomy, 2009)Thyroid carcinoma is the most common endocrine malignancy, with an incidence of approximately eighty cases per year in Ireland and thirty seven thousand cases per year in the United States. While thyroid cancer may be ... -
Molecular markers in cervical cancer
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Histopathology & Morbid Anatomy, 2004)Despite the introduction of the Papanicolaou (Pap) test carcinoma of the cervix remains one of the most common malignancies amongst women worldwide. It is hoped that the use of HPV testing and molecular biomarkers in ...