Show simple item record

dc.contributor.authorKENNY, ROSE ANNE
dc.contributor.authorROMERO-ORTUNO, ROMAN
dc.contributor.authorFAN, CHIE WEI
dc.contributor.authorFORAN, TIM
dc.date.accessioned2011-07-01T14:40:13Z
dc.date.available2011-07-01T14:40:13Z
dc.date.issued2011
dc.date.submitted2011en
dc.identifier.citationR Romero-Ortuno, L Cogan, T Foran, RA Kenny, CW Fan., Continuous noninvasive orthostatic blood pressure measurements and their relationship with orthostatic intolerance, falls, and frailty in older people., Journal of the American Geriatrics Society, 59, 4, 2011, 655-65en
dc.identifier.otherY
dc.identifier.urihttp://hdl.handle.net/2262/57382
dc.descriptionPUBLISHEDen
dc.description.abstractOBJECTIVES: To identify morphological orthostatic blood pressure (BP) phenotypes in older people and assess their correlation with orthostatic intolerance (OI), falls, and frailty and to compare the discriminatory performance of a morphological classification with two established orthostatic hypotension (OH) definitions: consensus (COH) and initial (IOH). DESIGN: Cross-sectional. SETTING: Geriatric research clinic. PARTICIPANTS: Four hundred forty-two participants (mean age 72, 72% female) without dementia or risk factors for autonomic neuropathy. MEASUREMENTS: Active lying-to-standing test monitored using a continuous noninvasive BP monitor. For the morphological classification, four orthostatic systolic BP variables were extracted (delta (baseline - nadir) and maximum percentage of baseline recovered by 30 seconds and 1 and 2 minutes) using the 5-second averages method and entered in K-means cluster analysis (three clusters). Main outcomes were OI, falls (?1 in past 6 months), and frailty (modified Fried criteria). RESULTS: The morphological clusters were small drop, fast overrecovery (n=112); medium drop, slow recovery (n=238); and large drop, nonrecovery (n=92). Their characterization revealed an increasing OI gradient (17.9%, 27.5%, and 44.6% respectively, P<.001) but no significant gradients in falls or frailty. The COH definition failed to reveal clinical differences between COH+ (n=416) and COH- (n=26) participants. The IOH definition resulted in a clinically meaningful separation between IOH+ (n=85) and IOH- (n=357) subgroups, as assessed according to OI (100% vs 11.5%, P<.001), falls (24.7% vs 10.4%, P<.001), and frailty (14.1% vs 5.4%, P=.005). CONCLUSION: It is recommended that the IOH definition be applied when taking continuous noninvasive orthostatic BP measurements in older people.en
dc.format.extent655-65en
dc.language.isoenen
dc.publisherAmerican Geriatrics Societyen
dc.relation.ispartofseriesJournal of the American Geriatrics Society;
dc.relation.ispartofseries59;
dc.relation.ispartofseries4;
dc.rightsYen
dc.subjectGerontologyen
dc.subjectBlood Pressureen
dc.titleContinuous noninvasive orthostatic blood pressure measurements and their relationship with orthostatic intolerance, falls, and frailty in older people.en
dc.typeJournal Articleen
dc.type.supercollectionscholarly_publicationsen
dc.type.supercollectionrefereed_publicationsen
dc.identifier.peoplefinderurlhttp://people.tcd.ie/rkenny
dc.identifier.peoplefinderurlhttp://people.tcd.ie/romeroor
dc.identifier.peoplefinderurlhttp://people.tcd.ie/fanc
dc.identifier.peoplefinderurlhttp://people.tcd.ie/tforan
dc.identifier.rssinternalid72396
dc.identifier.rssurihttp://dx.doi.org/10.1111/j.1532-5415.2011.03352.xen


Files in this item

This item appears in the following Collection(s)

Show simple item record