dc.contributor.author | KENNY, ROSE ANNE | |
dc.contributor.author | ROMERO-ORTUNO, ROMAN | |
dc.contributor.author | FAN, CHIE WEI | |
dc.contributor.author | FORAN, TIM | |
dc.date.accessioned | 2011-07-01T14:40:13Z | |
dc.date.available | 2011-07-01T14:40:13Z | |
dc.date.issued | 2011 | |
dc.date.submitted | 2011 | en |
dc.identifier.citation | R Romero-Ortuno, L Cogan, T Foran, RA Kenny, CW Fan., Continuous noninvasive orthostatic blood pressure measurements and their relationship with orthostatic intolerance, falls, and frailty in older people., Journal of the American Geriatrics Society, 59, 4, 2011, 655-65 | en |
dc.identifier.other | Y | |
dc.identifier.uri | http://hdl.handle.net/2262/57382 | |
dc.description | PUBLISHED | en |
dc.description.abstract | OBJECTIVES:
To identify morphological orthostatic blood pressure (BP) phenotypes in older people and assess their correlation with orthostatic intolerance (OI), falls, and frailty and to compare the discriminatory performance of a morphological classification with two established orthostatic hypotension (OH) definitions: consensus (COH) and initial (IOH).
DESIGN:
Cross-sectional.
SETTING:
Geriatric research clinic.
PARTICIPANTS:
Four hundred forty-two participants (mean age 72, 72% female) without dementia or risk factors for autonomic neuropathy.
MEASUREMENTS:
Active lying-to-standing test monitored using a continuous noninvasive BP monitor. For the morphological classification, four orthostatic systolic BP variables were extracted (delta (baseline - nadir) and maximum percentage of baseline recovered by 30 seconds and 1 and 2 minutes) using the 5-second averages method and entered in K-means cluster analysis (three clusters). Main outcomes were OI, falls (?1 in past 6 months), and frailty (modified Fried criteria).
RESULTS:
The morphological clusters were small drop, fast overrecovery (n=112); medium drop, slow recovery (n=238); and large drop, nonrecovery (n=92). Their characterization revealed an increasing OI gradient (17.9%, 27.5%, and 44.6% respectively, P<.001) but no significant gradients in falls or frailty. The COH definition failed to reveal clinical differences between COH+ (n=416) and COH- (n=26) participants. The IOH definition resulted in a clinically meaningful separation between IOH+ (n=85) and IOH- (n=357) subgroups, as assessed according to OI (100% vs 11.5%, P<.001), falls (24.7% vs 10.4%, P<.001), and frailty (14.1% vs 5.4%, P=.005).
CONCLUSION:
It is recommended that the IOH definition be applied when taking continuous noninvasive orthostatic BP measurements in older people. | en |
dc.format.extent | 655-65 | en |
dc.language.iso | en | en |
dc.publisher | American Geriatrics Society | en |
dc.relation.ispartofseries | Journal of the American Geriatrics Society; | |
dc.relation.ispartofseries | 59; | |
dc.relation.ispartofseries | 4; | |
dc.rights | Y | en |
dc.subject | Gerontology | en |
dc.subject | Blood Pressure | en |
dc.title | Continuous noninvasive orthostatic blood pressure measurements and their relationship with orthostatic intolerance, falls, and frailty in older people. | en |
dc.type | Journal Article | en |
dc.type.supercollection | scholarly_publications | en |
dc.type.supercollection | refereed_publications | en |
dc.identifier.peoplefinderurl | http://people.tcd.ie/rkenny | |
dc.identifier.peoplefinderurl | http://people.tcd.ie/romeroor | |
dc.identifier.peoplefinderurl | http://people.tcd.ie/fanc | |
dc.identifier.peoplefinderurl | http://people.tcd.ie/tforan | |
dc.identifier.rssinternalid | 72396 | |
dc.identifier.rssuri | http://dx.doi.org/10.1111/j.1532-5415.2011.03352.x | en |