Browsing Biochemistry by Sponsor "Enterprise Ireland"
Now showing items 1-17 of 17
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Adenylate cycalse toxin of Bordetella pertussis inhibits TLR-induced IRF-1 and IRF-8 activation and IL-12 production and enhances IL-10 through MAPK activation in dendritic cells
(Society of Leukocyte Biology, 2008)Adenylate cyclase toxin (CyaA) of Bordetella pertussis binds to CD11b/CD18 on macrophages and dendritic cells (DC) and confers virulence to the bacteria by subverting innate immune responses of the host. We have previously ... -
Adenylate cyclase toxin from Bordetella pertussis synergises with lipopolysaccharide to promote innate IL-10 production and enhance the induction of Th2 and regulatory T cells
(American Society for Microbiology, 2004)Adenylate cyclase toxin (CyaA) from Bordetella pertussis can subvert host immune responses allowing bacterial colonization. Here we have examined its adjuvant and immunomodulatory properties and the possible contribution ... -
Bordetella pertussis adenylate cyclase toxin modulates innate and adaptive immune responses: distinct roles for acylation and enzymatic activity in immunomodulation and cell death
(The American Association of Immunologists, 2005)Adenylate cyclase toxin (CyaA) of Bordetella pertussis belongs to the repeat in toxin family of pore-forming toxins, which require posttranslational acylation to lyse eukaryotic cells. CyaA modulates dendritic cell (DC) ... -
Caspase-11 regulates the tumour suppressor function of STAT1 in a murine model of colitis-associated carcinogenesis
(2019)Murine inflammatory caspase-11 has an important role in intestinal epithelial inflammation and barrier function. Activation of the non-canonical inflammasome, mediated by caspase-11, serves as a regulatory pathway for the ... -
CRISPR Gene Editing Approaches in the Study of Allergy and Infertility
(Trinity College Dublin. School of Biochemistry & Immunology. Discipline of Biochemistry, 2019) -
Divergent roles for Ras and Rap in the activation of p38 mitogen-activated protein kinase by interleukin-1
(The American Society for Biochemistry and Molecular Biology, 2000)We have found that lethal toxin from Clostridium sordellii, which specifically inactivates the low molecular weight G proteins Ras, Rap, and Rac, inhibits the activation of p38 mitogen-activated protein kinase (MAPK) by ... -
Dual targeting of tumour cells and host endothelial cells by novel microtubule-targeting agents, pyrrolo-1,5-benzoxazepines.
(Springer, 2010)Advanced hormone-refractory prostate cancer is associated with poor prognosis and limited treatment options. Members of the pyrrolo-1,5-benzoxazepine (PBOX) family of compounds exhibit anti-cancer properties in cancer cell ... -
Epithelial expression of inflammatory caspases-4 and -5 is specific to malignancy in colorectal cancer patients.
(American Gastroenterology Association (AGA), 2016) -
Insights into the mode of action of a putative zinc transporter CzrB in Thermus thermophilus.
(2008)The crystal structures of the cytoplasmic domain of the putative zinc transporter CzrB in the apo and zinc-bound forms reported herein are consistent with the protein functioning in vivo as a homodimer. NMR, X-ray scattering, ... -
Lead identification of beta-lactam and related imine inhibitors of the molecular chaperone heat shock protein 90
(Elsevier, 2011)Heat shock protein 90 is an emerging target for oncology therapeutics. Inhibitors of this molecular chaperone, which is responsible for the maintenance of a number of oncogenic proteins, have shown promise in clinical ... -
Lead identification of conformationally restricted ?-lactam type combretastatin analogues: synthesis, antiproliferative activity and tubulin targeting effects
(Elsevier, 2010)The synthesis and study of the structure-activity relationships of a series of rigid analogues of combretastatin A-4 are described which contain the 1,4-diaryl-2-azetidinone (?-lactam) ring system in place of the usual ... -
A method to predict residues conferring functional differences between related proteins: application to MAP kinase pathways
(The Protein Society, 2000)Physicochemical properties are potentially useful in predicting functional differences between aligned protein subfamilies. We present a method that considers physicochemical properties from ancestral sequences predicted ... -
Ras participates in the activation of p38 MAPK by interleukin-1 by associating with IRAK, IRAK2, TRAF6, and TAK-1
(American Society for Biochemistry and Molecular Biology, 2002)Interleukin-1 (IL-1) activates p38 MAP kinase via the small G protein Ras, and this activity can be down-regulated by another small G protein Rap. Here we have further investigated the role of Ras and Rap in p38 MAPK ... -
Regulatory T cells: friend or foe in immunity to infection.
(Nature, 2004)Homeostasis in the immune system is dependant on a balance between responses that control infection and tumours and the reciprocal responses that prevent inflammation and autoimmune diseases. It is now recognized that ... -
A Role for TLR4 in Clostridium difficile Infection and the Recognition of Surface Layer Proteins
(2011)Clostridium difficile is the etiological agent of antibiotic-associated diarrhoea (AAD) and pseudomembranous colitis in humans. The role of the surface layer proteins (SLPs) in this disease has not yet been fully explored. ... -
Synthesis and in vitro toxicity of 4-MTA, its characteristic clandestine synthesis byproducts and related sulphur substituted a-alkylthioamphetamines
(2010)4-Methylthioamphetamine (4-MTA) is recognised as a 3,4-methylenedioxymethamphetamine (MDMA)-like drug of abuse. Such amphetamine-type drugs often contain byproducts of uncontrolled, illegal clandestine synthetic processes. ...