Evolutionary Origins of the Fumonisin Secondary Metabolite Gene Cluster in Fusarium verticillioides and Aspergillus niger
Citation:
Nora Khaldi and Kenneth H. Wolfe, Evolutionary Origins of the Fumonisin Secondary Metabolite Gene Cluster in Fusarium verticillioides and Aspergillus niger, International Journal of Evolutionary Biology, 2011, 423821, 2011, 7Download Item:
Evolutionary Origins of the Fumonisin SecondaryMetabolite Gene Cluster in Fusarium verticillioides and Aspergillus niger.pdf (Published (publisher's copy) - Peer Reviewed) 811.2Kb
Abstract:
The secondary metabolite gene clusters of euascomycete fungi are among the largest known clusters of functionally related genes
in eukaryotes. Most of these clusters are species specific or genus specific, and little is known about how they are formed during
evolution. We used a comparative genomics approach to study the evolutionary origins of a secondary metabolite cluster that
synthesizes a polyketide derivative, namely, the fumonisin (FUM) cluster of Fusarium verticillioides, and that of Aspergillus niger
another fumonisin (fumonisin B) producing species.We identified homologs in other euascomycetes of the Fusarium verticillioides
FUM genes and their flanking genes.We discuss fourmodels for the origin of the FUM cluster in Fusarium verticillioides and argue
that two of these are plausible: (i) assembly by relocation of initially scattered genes in a recent Fusarium verticillioides; or (ii)
horizontal transfer of the FUM cluster from a distantly related Sordariomycete species. We also propose that the FUM cluster was
horizontally transferred into Aspergillus niger, most probably from a Sordariomycete species.
Author's Homepage:
http://people.tcd.ie/khwolfeDescription:
PUBLISHED
Author: WOLFE, KENNETH
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SAGE-HindawiType of material:
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Series/Report no:
International Journal of Evolutionary Biology;2011;
423821;
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Full text availableKeywords:
Immunology, Genetics, Fusarium verticillioides, Aspergillus nigerLicences: