Browsing Medical Gerontology by Subject "Immunology, Inflammation & Infection"
Now showing items 1-20 of 24
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ACE gene I/D polymorphism and severity of SARS-CoV-2 infection in hospitalized patients: a metanalysis
(2021)Background Hypertension and type 2 diabetes increase the risk of severe SARS-CoV-2 infection. On the other hand, homozygous ACE deletion polymorphism (DD) has been associated with these two diseases and risk of acute ... -
Association between low serum vitamin d and Increased mortality and severity due to COVID-19: reverse causality?
(2022)We are very close to completing two years since the start of the COVID-19 pandemic. Even though vaccines have been developed and applied to more than 4 billion people in the world, SARS-CoV-2 continues to be a challenge ... -
Biomarker Signatures of Two Phenotypical Pre-Frailty Types in The Irish Longitudinal Study on Ageing
(2022)Abstract: We investigated the biomarker signatures of two previously reported phenotypical prefrailty (PF) types in the first wave of The Irish Longitudinal Study on Ageing (TILDA): PF1 (unexplained weight loss and/or ... -
Biomarkers of delirium risk in older adults: a systematic review and meta-analysis
(2023)Delirium is a neuropsychiatric syndrome associated with increased morbidity and mortality in older patients. The aim of this study was to review predictive biomarkers of delirium in older patients to gain insights into ... -
Characterising the Blood Pressure Response to Physical Counterpressure Manoeuvres Using Surface Electromyography in Adults with Long Covid
(2023)Objective: Orthostatic intolerance (OI) is common in Long Covid. Physical counterpressure manoeuvres (PCM) may improve OI in other disorders. We characterised the blood pressure-rising effect of PCM using surface ... -
Characterising the Blood Pressure Response to Physical Counterpressure Manoeuvres Using Surface Electromyography in Adults with Long Covid
(2023)Objective: Orthostatic intolerance (OI) is common in Long Covid. Physical counterpressure manoeuvres (PCM) may improve OI in other disorders. We characterised the blood pressure-rising effect of PCM using surface ... -
Clinical features and mortality predictors of older hospitalized patients with severe COVID-19 in Lima, Per?
(2022)Background and aims. The objective of our study was to describe the clinical features of severe COVID-19 in older (compared to younger) hospitalized patients in a tertiary care centre in Lima, Perú. Methods. A retrospective ... -
Comprehensive clinical characterisation of brain fog in adults reporting long COVID symptoms
(2022)(1) Introduction: A subset of individuals experiencing long COVID symptoms are affected by ‘brain fog’, a lay term that often refers to general cognitive dysfunction but one that is still poorly characterised. In this ... -
Control of HIV infection by IFN-α: implications for latency and a cure.
(Springer, 2018)Viral infections, including HIV, trigger the production of type I interferons (IFNs), which in turn, activate a signalling cascade that ultimately culminates with the expression of anti-viral proteins. Mounting evidence ... -
Effect of immunology biomarkers associated with hip fracture and fracture risk in older adults
(2023)Osteoporosis is a skeletal disease that can increase the risk of fractures, leading to adverse health and socioeconomic consequences. However, current clinical methods have limitations in accurately estimating fracture ... -
Integrating genotypic data with transcriptomic and proteomic data.
(2002)Historically genotypic variation has been detected at the phenotypic level, at the metabolic level, and at the protein chemistry level. Advances in technology have allowed its direct visualisation at the level of DNA ... -
Metformin therapy and severity and mortality of SARS-CoV-2 infection: a meta-analysis
(2021)Background: It has been postulated that metformin could have anti-SARS-CoV-2 action. This raises the hypothesis that people who take metformin may have lower SARS-CoV-2 severity and/or mortality. Objective To conduct a ... -
New self-reported exhaustion during the COVID-19 Pandemic
(2021)In 2020, participants from The Irish Longitudinal Study on Ageing were surveyed to provide vital and timely information on lived experiences of older adults during the SARS-CoV-2 pandemic. During 2020, older adults experienced ... -
A novel methodology for the synchronous collection and multimodal visualization of continuous neurocardiovascular and neuromuscular physiological data in adults with long COVID
(2022)Reports suggest that adults with post-COVID-19 syndrome or long COVID may be affected by orthostatic intolerance syndromes, with autonomic nervous system dysfunction as a possible causal factor of neurocardiovascular ... -
Orthostatic intolerance in adults reporting long COVID symptoms was not associated with postural orthostatic tachycardia syndrome
(2022)In this observational cross-sectional study, we investigated predictors of orthostatic intolerance (OI) in adults reporting long COVID symptoms. Participants underwent a 3-min active stand (AS) with Finapres® NOVA, followed ... -
A pharmacological perspective of Chloroquine in SARS-CoV-2 infection
(2020)The pandemic caused by the Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) is having serious consequences on health and the economy worldwide. All evidence-based treatment strategies need to be ... -
Predictors of submaximal exercise test attainment in adults reporting long COVID symptoms
(2022)Adults with long COVID often report intolerance to exercise. Cardiopulmonary exercise testing (CPET) has been used in many settings to measure exercise ability but has been conducted in a few long COVID cohorts. We conducted ...