Asymmetric acyl-transfer promoted by readily assembled chiral 4-N,N-dialkylaminopyridine derivatives
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2006Citation:
Ciaran O. Dalaigh, Stephen J. Hynes, John E. O'Brien, Thomas McCabe, Declan J. Maher, Graeme W. Watson and Stephen J. Connon, Asymmetric acyl-transfer promoted by readily assembled chiral 4-N,N-dialkylaminopyridine derivatives , Organic and Biomolecular Chemistry, 4, 14, 2006, 2785-2793Download Item:
Abstract:
The development of a new class of chiral 4-N,N-dialkylaminopyridine acyl-transfer catalysts capable of exploiting both van der Waals (?) and H-bonding interactions to allow remote chiral information to stereochemically control the kinetic resolution of sec-alcohols with moderate to excellent selectivity (s = 6?30). Catalysts derived from (S)-?,?-diarylprolinol are considerably superior to analogues devoid of a tertiary hydroxyl moiety and possess high activity and selectivity across a broad range of substrates.
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http://people.tcd.ie/connonshttp://people.tcd.ie/tmccabe
http://people.tcd.ie/watsong
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Royal Society of ChemistryType of material:
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Organic and Biomolecular Chemistry;4;
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Biochemistry, CatalystsMetadata
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