The enantioselective benzoin condensation promoted by chiral triazolium precatalysts: stereochemical control via hydrogen bonding.
Item Type:Journal Article
Citation:S. E. O Toole and S. J. Connon, The enantioselective benzoin condensation promoted by chiral triazolium precatalysts: stereochemical control via hydrogen bonding., Organic Biomolecular Chemistry, 7, 17, 2009, 3584-3593
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The design of a new class of triazolium ion precatalysts incorporating protic substituents is described. These materials promote the enantioselective benzoin condensation of a range of aromatic aldehydes (1?62% ee). Catalyst evaluation studies strongly support the involvement of hydrogen bond donation by the catalyst in the stereocentre-forming step of the catalytic cycle.
Science Foundation Ireland (SFI)
Author: CONNON, STEPHEN
Type of material:Journal Article
Series/Report no:Organic Biomolecular Chemistry
Availability:Full text available
Subject (TCD):Nanoscience & Materials