Browsing School of Medicine by Title
Now showing items 2498-2517 of 3149
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Quantification of unfractionated heparin in human plasma and whole blood by means of novel fluorogenic anti-FXa assays
(Elsevier, 2011)Novel and sensitive plate-based fluorogenic anti-factor Xa (FXa) assays were investigated to quantify unfractionated heparin (UFH) in human plasma and whole blood within the therapeutic ranges of 0-1.6 U/mL and 0?0.8 U/mL, ... -
Quantum dots in nanomedicine: Recent trends, advances and unresolved issues
(2015)The review addresses the current state of progress in the use of ultra-small nanoparticles from the category of quantum dots (QDs), which presently embraces a widening range of nanomaterials of different nature, including ... -
"Managed competition" for Ireland? The single versus multiple payer debate.
(2014)Background A persistent feature of international health policy debate is whether a single-payer or multiple-payer system can offer superior performance. In Ireland, a major reform proposal is the introduction of ‘managed ... -
r2VIM: A new variable selection method for random forests in genome-wide association studies
(2016)Background Machine learning methods and in particular random forests (RFs) are a promising alternative to standard single SNP analyses in genome-wide association studies (GWAS). RFs provide variable importance measures ... -
RACK1 to the future – a historical perspective.
(2013)This perspective summarises the first and long overdue RACK1 meeting held at the University of Limerick, Ireland, May 2013, in which RACK1 ’ s role in the immune system, the heart and the brain were discussed and ... -
RAD51 135G>C modifies breast cancer risk among BRCA2 mutation carriers: Results from a combined analysis of 19 studies
(The American Society of Human Genetics, 2007)Though much progress has been made in understanding the role of two major high-risk breast cancer (BC) susceptibility genes, BRCA1 and BRCA2, it remains unclear what causes the observed variation in risk between mutation ... -
Radial glial cells: Key organisers in CNS development.
(2014)Radial glia are elongated bipolar cells present in the CNS during development. Our understanding of the unique roles these cells play has significantly expanded in the last decade. Historically, radial glial cells were ... -
Radiation and immunotherapy in upper gastrointestinal cancers: The current state of play
(2021)Radiotherapy remains one of the contemporary cornerstones of cancer treatment in the neoadjuvant, curative, adjuvant and palliative settings, either in isolation or as a multimodal approach. Moreover, recent advances in ... -
Radiation oncology safety information system (ROSIS) : a reporting and learning system for radiation oncology
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Radiation Therapy, 2011)Background and Purpose: Incident reporting is a recognised tool for learning from incidents. The Radiation Oncology Safety Information System (ROSIS) was established in 2001, to collate and share information on incidents ... -
Radiation Therapists role in support patients in Radiation Oncology Departments
(2009-03-11)Despite advances in medical technology, cancer is still one of the leading causes of death globally, leaving many patients to deal with the emotional and psychological aspects associated with cancer and its treatment ... -
Radioiodine Dosimetry for Benign and Malignant Thyroid Disease
(Trinity College Dublin. School of Medicine. Discipline of Clinical Medicine, 2023)Thyroid diseases are a common clinical disorder with 5-10% diagnosed as thyroid cancer. The published guidelines that provide clinical guidance for the diagnosis, treatment and management of thyroid diseases, based on a ... -
Radiotherapy, immunotherapy, and the tumour microenvironment: Turning an immunosuppressive milieu into a therapeutic opportunity
(2021)Immune checkpoint blockade (ICB) has revolutionised the treatment of solid tumours, yet most patients do not derive a clinical benefit. Resistance to ICB is often contingent on the tumour microenvironment (TME) and modulating ... -
Radiotherapy: Seizing the opportunity in cancer care
(ESTRO, 2019)The incidence of cancer is increasing, resulting in a rising demand for high‑quality cancer care. In 2018, there were close to 4.23 million new cases of cancer in Europe, and this number is predicted to rise by almost ... -
A randomised controlled trial evaluating family mediated exercise (FAME) therapy following stroke
(BioMed Central, 2008)Stroke is a leading cause of disability among adults worldwide. Evidence suggests that increased duration of exercise therapy following stroke has a positive impact on functional outcome following stroke. The main objective ... -
A randomised controlled trial evaluating the effect of an individual auditory cueing device on freezing and gait speed in people with Parkinson's disease
(BioMed Central, 2008)Parkinson's disease is a progressive neurological disorder resulting from a degeneration of dopamine producing cells in the substantia nigra. Clinical symptoms typically affect gait pattern and motor performance. Evidence ... -
A randomised, double-blind, placebo-controlled, pilot trial of intravenous plasma purified alpha-1 antitrypsin for SARS-CoV-2-induced Acute Respiratory Distress Syndrome: a structured summary of a study protocol for a randomised, controlled trial
(2021)The primary objective is to demonstrate that, in patients with PCR-confirmed SARS-CoV-2 resulting in Acute Respiratory Distress Syndrome (ARDS), administration of 120mg/kg of body weight of intravenous Prolastin®(plasma-purified ... -
A randomized controlled trial of cognitive remediation for a national cohort of forensic patients with schizophrenia or schizoaffective disorder
(2019)Background: Evidence is accumulating that Cognitive Remediation Training (CRT) is effective for ameliorating cognitive deficits experienced by patients with schizophrenia and accompanying functional impairment. There has ... -
A Randomized, Controlled Trial With 6-Month Follow-Up of Repetitive Transcranial Magnetic Stimulation and Electroconvulsive Therapy for Severe Depression
(American Psychiatric Association, 2007)OBJECTIVE: Repetitive transcranial magnetic stimulation (rTMS) has been reported to be as effective as electroconvulsive therapy (ECT) for major depression. The authors conducted a multicenter randomized, controlled trial ... -
A randomized, double-blind, placebo-controlled trial of intravenous alpha-1 antitrypsin for ARDS secondary to COVID-19
(2022)Background: Patients with severe coronavirus disease 2019 (COVID-19) develop a febrile pro-inflammatory cytokinemia with accelerated progression to acute respiratory distress syndrome (ARDS). Here we report the results of ... -
RanGTPase: A Candidate for Myc-Mediated Cancer Progression
(2013)BACKGROUND: Ras-related nuclear protein (Ran) is required for cancer cell survival in vitro and human cancer progression, but the molecular mechanisms are largely unknown. METHODS: We investigated the effect of the ...
